X. Qu

Glutathione metabolism impacts fungal virulence by modulating the redox environment

This study shows that glutathione metabolism in Cryptococcus neoformans affects virulence by modulating redox processes and melanin production in a murine infection model.

HIGH THROUGHPUT QUANTITATION OF HUMAN NEUTROPHIL RECRUITMENT AND FUNCTIONAL RESPONSES IN AN AIR-BLOOD BARRIER ARRAY

The paper develops a high-throughput assay to study neutrophil recruitment and function in an air-blood barrier array, showing improved throughput and sample efficiency compared to existing methods.

Polybacterial intracellular coinfection of epithelial stem cells in periodontitis

This study identifies polybacterial intracellular co-infection in human periodontal epithelial cells, revealing its proinflammatory effects and potential role in chronic diseases.

Genome duplications, genomic conflict, and rapid phenotypic evolution characterize the Cretaceous radiation of Fagales

This study examines the relationship between phenotypic and genomic evolution in Fagales, finding an 'early burst' model of diversification linked to gene duplication and genomic conflict during the Cretaceous.

EZH2 inhibition promotes tumor immunogenicity in lung squamous cell carcinomas

EZH2 inhibition increases immune checkpoint inhibitor response in lung squamous cell carcinomas by enhancing antigen presentation and immune cell infiltration.

Comprehensive characterization of tumor microenvironment in colorectal cancer via histopathology-molecular analysis

This study characterizes the tumor microenvironment in colorectal cancer using multi-omics and spatial analysis, identifying four subtypes with distinct features and therapeutic responses.

Spike-specific CXCR3+ TFH cells play a dominant functional role in supporting antibody responses in SARS-CoV-2 infection and vaccination

This study identifies spike-specific CXCR3+ TFH cells as key drivers of long-term antibody responses in SARS-CoV-2 infection and vaccination.

The microtubule-associated protein SlMAP70 interacts with SlIQD21 and regulates fruit shape formation in tomato

This study identifies SlMAP70 as a regulator of tomato fruit shape by interacting with SlIQD21 and modulating microtubule organization during fruit development.

A Modular Chemoenzymatic Approach to C14-Functionalized Steroids

This paper develops a modular chemoenzymatic method to synthesize diverse C14-functionalized steroids using a novel CYP14A enzyme and its variants.

An Igh novel enhancer modulates antigen receptor diversity by determining locus conformation

The paper identifies a novel enhancer, NE1, that modulates Igh locus conformation and influences V(D)J recombination by altering chromatin structure and VH gene usage.

Stable m7G Cap-Distal 5'UTR Hairpin Structure Mediates Distinct 40S and 60S Binding Dynamics

This study uses single-molecule fluorescence microscopy to show that stable 5'UTR hairpins reduce 60S recruitment and translation efficiency by destabilizing 40S-mRNA interactions.

m7G cap-eIF4E interaction stimulates polysome formation by enhancing first-round initiation kinetics

This study investigates how m7G cap-eIF4E interactions influence polysome formation kinetics using single-molecule tracking in wheat germ and HeLa extracts.

Population genomics of Salmonella enterica serovar Weltevreden ST365, an emerging predominant causative agent of diarrheal disease

This study identifies ST365 as the predominant causative agent of S. Weltevreden diarrhea outbreaks globally and discovers a novel virulence plasmid associated with its pathogenicity.

Airway epithelial integrin β4 suppresses allergic inflammation by decreasing CCL17 production

This study shows that ITGB4 in airway epithelial cells reduces CCL17 production, thereby suppressing Th2 responses and allergic inflammation in asthma.

Blimp-1 in adipose resident Tregs controls adipocyte beiging and obesity

This study shows that Blimp-1 in adipose Tregs suppresses IL-10, reducing beiging and increasing obesity risk, while its ablation improves insulin sensitivity and reduces weight in mice.

Activity-dependent nucleation of dynamic microtubules at presynaptic boutons is required for neurotransmission

The paper shows that activity-dependent MT nucleation at presynaptic boutons is essential for neurotransmission by enabling SV transport and exocytosis.

Androgen-dmrt1 positive feedback programs the rice field eel (Monopterus albus) sex transdifferentiation

This study identifies androgen-dmrt1 positive feedback as a mechanism driving sex reversal in rice field eel by analyzing gene regulation and enzyme expression.