Author

L. N. Lam

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 7

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Research Focus:host-pathogen & immune response· 6 Research Focus:cell signaling & trafficking· 3 Organism:human· 3 Assay:proteomics· 3 Organism:E. coli· 2 Organism:bacteria (other)· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

J. A. Lemos· 3 shared K. A. Kline· 3 shared A. Matysik· 2 shared K. Kline· 2 shared A. Cazenave-Gassiot· 1 shared A. Flores-Mireles· 1 shared A. Koh· 1 shared A. Sinha· 1 shared

Activity by Year

2017-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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3 shared papersMicrobiology

J. A. Lemos

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Identification of Multiple Iron Uptake Mechanisms in Enterococcus faecalis and Their Relationship to Virulence

J. A. Lemos, D. N. Brunson, L. N. Lam, C. Colomer-Winter

This study identifies five iron uptake systems in Enterococcus faecalis and shows their collective role in virulence and iron homeostasis, with heme utilization critical for systemic infection.

bioRxiv · Nov 4, 2022 · PreprintMicrobiology

An RNA modification enzyme directly senses reactive oxygen species for translational regulation in Enterococcus faecalis

W. L. Lee, A. Sinha, L. N. Lam, H. L. Loo, J. Liang, P. Ho, C. Liang, C. Chan, T. Begley, K. A. Kline, P. Dedon

The paper identifies an RNA modification enzyme in Enterococcus faecalis that senses reactive oxygen species and regulates translation of stress-response proteins.

bioRxiv · Oct 12, 2022 · PreprintMicrobiology

Enterococcus faecalis antagonizes Pseudomonas aeruginosa growth in polymicrobial biofilms

C. A. Z. Tan, L. N. Lam, G. Biukovic, E. Y.-C. Soh, X. W. Toh, J. A. Lemos, K. A. Kline

This study shows that Enterococcus faecalis inhibits Pseudomonas aeruginosa growth in iron-restricted biofilms through lactic acid production and pH reduction.

bioRxiv · Jan 18, 2022 · PreprintMicrobiology

c-di-AMP is essential for the virulence of Enterococcus faecalis

S. Kundra, L. N. Lam, J. K. Kajfasz, L. Casella, M. J. Andersen, J. Abranches, A. Flores-Mireles, J. A. Lemos

This study shows that c-di-AMP is essential for the virulence of Enterococcus faecalis, as its absence or accumulation impairs cell fitness and pathogenicity in multiple models.

bioRxiv · May 19, 2021Microbiology

The composition and function of Enterococcus faecalismembrane vesicles

I. Afonina, B. Tien, Z. Nair, A. Matysik, L. N. Lam, M. Veleba, A. Koh, R. Rashid, A. Cazenave-Gassiot, M. R. Wenk, S. Nyunt, K. Kline

This study identifies and functionally characterizes membrane vesicles from Enterococcus faecalis, revealing unique lipid and protein profiles and their potential role in virulence.

bioRxiv · Jan 28, 2021 · PreprintMicrobiology

Enterococcus faecalis manganese exporter MntE alleviates manganese toxicity and is required for mouse gastrointestinal colonization

L. N. Lam, J. J. Wong, K. K. L. Chong, K. A. Kline

bioRxiv · Feb 6, 2020Microbiology

Extracellular Electron Transfer Powers Enterococcus faecalis Biofilm Metabolism

D. Keogh, L. N. Lam, L. Doyle, A. Matysik, S. Pavagadhi, S. Umashankar, J. L. Dale, C. B. Boothroyd, G. M. Dunny, S. Swarup, R. B. H. Williams, E. Marsili, K. Kline

This study identifies a novel iron-dependent extracellular electron transfer (EET) mechanism in Enterococcus faecalis biofilms that enhances growth and matrix properties.

bioRxiv · Apr 24, 2017Microbiology