J. Longo

NRF2-dependent regulation of the prostacyclin receptor PTGIR drives CD8 T cell exhaustion

This study identifies the KEAP1-NRF2 pathway as a driver of CD8 T cell exhaustion by regulating the prostacyclin receptor PTGIR.

Acod1 Expression in Cancer Cells Promotes Immune Evasion through the Generation of Inhibitory Peptides

This study shows that Acod1 in cancer cells promotes immune evasion by releasing inhibitory peptides, not ITA, and that reducing Acod1 can make tumors responsive to PD-1 therapy.

SLC3A2 N-glycosylation and alternate evolutionary trajectories for amino acid metabolism

This study investigates how N-glycosylation sites on SLC3A2 evolve and regulate amino acid transport and redox balance, revealing their role in cellular trafficking and bird evolution.

Ketolysis is a metabolic driver of CD8+ T cell effector function through histone acetylation

This study identifies ketone bodies as essential for CD8+ T cell metabolism and effector function through histone acetylation regulation.

Computational pharmacogenomics screen identifies synergistic statin-compound combinations as anti-breast cancer therapies

Modeling the MYC-driven normal-to-tumour switch in breast cancer.

This study creates an in vivo model of MYC-driven breast cancer by combining PIK3CAH1047R mutation with deregulated MYC, showing a normal-to-tumour switch and dependence on MYC for tumor growth.