L. Zhao

The paper describes the establishment of hTERT-immortalized RPTE cells for studying BK polyomavirus infection.

The paper introduces a timescale-specific variance ratio metric to quantify compensatory dynamics in ecological communities and applies it to grassland data, showing variation in compensation across timescales.

This study shows diurnal variation in xylem water isotopes biases root water uptake depth estimates and proposes monitoring sap flow and soil water potential to improve accuracy.

This study uses single-cell RNA-seq to analyze de novo gene expression and mutational patterns in Drosophila testis across spermatogenesis.

The paper constructs a genealogy of Rep proteins in CRESS DNA viruses using a custom amino acid substitution model, revealing a single origin of intron-containing Reps and challenging the monophyly of Geminiviridae.

The paper identifies CHET3, a selective TASK-3 activator, and demonstrates its analgesic effects in pain models, highlighting TASK-3 as a novel non-opioid analgesic target.

This study shows that targeting glutamine metabolism in tumors reduces MDSC generation, increases inflammatory macrophages, and enhances anti-tumor immunity, making checkpoint-resistant tumors responsive to immunotherapy.

This study uses single particle cryo-EM to determine the structure of 52 kDa streptavidin at 3.2 Angstrom resolution, demonstrating the feasibility of high-resolution imaging for small molecules.

This study evaluates the efficacy and adverse effects of antibiotics in treating M. abscessus pulmonary disease, finding that four antibiotics correlate with treatment success but are associated with severe side effects.

This study identifies a Clostridia-rich microbiota as a contributor to excessive bile acid excretion in IBS-D patients through metagenomic and metabolomic analyses.

This study investigates the nonreciprocal and conditional cooperativity between Sox2 and Oct4 in nucleosome targeting using single-molecule fluorescence microscopy.

This study shows that PIKfyve deficiency in myeloid cells impairs lysosomal function, leading to systemic inflammation and tissue infiltration in mice.

This study identifies the RhoA-myosin II axis as a mechanism enabling cancer cells to resist mechanical destruction by hemodynamic forces in circulation.

This study identifies the Kp citrate synthase gene gltA as critical for metabolic flexibility during infection, showing organ-specific fitness defects in lung and gut colonization.

This study compares bacterial composition and functional differences between cancerous and noncancerous ovarian tissues using 16S rRNA sequencing and metagenomic predictions.

This study shows that SCFAs from gut microbiota stimulate GLP-1 secretion in chickens, which suppresses hepatic lipogenesis.

This study identifies and characterizes a novel pic gene cluster in Alcaligenes faecalis JQ135 responsible for complete picolinic acid degradation into the tricarboxylic acid cycle.

The paper identifies HCSs associated with AT-less type I PKSs through genome mining and reveals their diversity across strains and soil samples.

This study identifies hemorrhagic myocarditis in mice induced by TLR-7 agonist using multi-parametric cardiac MRI, showing distinct T1, T2, and T2* relaxation patterns.

This study demonstrates that tungsten oxide nanodots exhibit strong antibacterial activity against both gram-negative and gram-positive bacteria, with enhanced efficacy under sunlight exposure and confirmed biocompatibility.

This study investigates whether BMP-2 promotes neovascularization directly or indirectly during bone regeneration and finds that it acts through paracrine signaling.

This paper shows that pre-existing host range mutations in RNA viruses restrict the genetic pathways available for further host range expansion, using bacteriophage phi6 as a model system.

The paper identifies structural and thermodynamic rules governing docking domain interactions in NRPSs, enabling predictable changes in peptide product spectra through residue exchange.

This study demonstrates that Nano-DOX-loaded TAM can reprogram GBM cells to an anti-GBM phenotype through DAMP emission, enhancing immune response and reducing tumor growth.

This paper identifies HpaM, a novel FAD-dependent monooxygenase in Alcaligenes faecalis JQ135, which catalyzes 2-decarboxylative hydroxylation of 5HPA to produce 2,5-DPH.

This study identifies Rab18 as a critical host factor for BKPyV infection through a whole-genome RNA interference screen in human renal cells.

The paper demonstrates the use of Volta phase plate with Cs-corrected TEM to achieve near-atomic resolution structures of apo-ferritin from over-focused images.

This study identifies TUG1 as an oncogenic lncRNA in pancreatic carcinoma that promotes progression by sponging miR-382 to upregulate EZH2.