Author

L. Zuzic

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biophysics· 3 Biochemistry· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Assay:structural biology· 3 Approach:deep learning· 2 Approach:experimental assay· 2 Research Focus:protein folding & dynamics· 2 Approach:statistical model· 2 Organism:virus· 2 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

P. J. Bond· 4 shared J. K. Marzinek· 3 shared J. Warwicker· 3 shared A. T. Shivgan· 2 shared F. Samsudin· 2 shared G. S. Anand· 2 shared M. Crispin· 2 shared A. Boags· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

4 shared papersBiophysics

P. J. Bond

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

A pH-dependent cluster of charges in a conserved cryptic pocket on flaviviral envelopes

L. Zuzic, J. K. Marzinek, G. S. Anand, J. Warwicker, P. J. Bond

This paper identifies a pH-dependent charge cluster in flaviviral envelope proteins that influences domain dissociation and fusion through molecular dynamics simulations.

bioRxiv · Jul 12, 2022Biophysics

Uncovering cryptic pockets in the SARS-CoV-2 spike glycoprotein

L. Zuzic, F. Samsudin, A. T. Shivgan, P. V. Raghuvamsi, J. K. Marzinek, A. Boags, C. Pedebos, N. K. Tulsian, J. Warwicker, P. MacAry, M. Crispin, S. Khalid, G. S. Anand, P. J. Bond

This study identifies a novel cryptic pocket on the SARS-CoV-2 spike protein using molecular dynamics simulations and validates its druggable potential through experimental methods.

bioRxiv · May 5, 2021Biophysics

Site-specific steric control of SARS-CoV-2 spike glycosylation

J. D. Allen, H. Chawla, F. Samsudin, L. Zuzic, A. T. Shivgan, Y. Watanabe, W.-T. He, S. Callaghan, G. Song, P. Yong, P. J. M. Brouwer, Y. Song, Y. Cai, H. M. E. Duyvesteyn, T. Malinauskas, , M. Crispin

The paper compares glycosylation patterns of recombinant SARS-CoV-2 spike proteins across labs with infectious virus S protein, finding conserved site-specific glycan maturation stalling linked to protein structure.

bioRxiv · Mar 8, 2021 · PreprintBiochemistry

A benzene-mapping approach for uncovering cryptic pockets in membrane-bound proteins

L. Zuzic, J. K. Marzinek, J. Warwicker, P. J. Bond

The paper introduces a benzene-mapping method using MD simulations to identify cryptic pockets in membrane-bound proteins, revealing a druggable pocket in the dengue virus E protein.

bioRxiv · Apr 4, 2020Biophysics