Author

N. K. Tulsian

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Biophysics· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Approach:mechanistic / dynamical model· 3 Research Focus:drug response / drug discovery· 2 Assay:proteomics· 2 Assay:structural biology· 2 Organism:virus· 2

Frequent Co-Authors

F. Samsudin· 3 shared G. S. Anand· 2 shared G. Yue· 2 shared J. Lescar· 2 shared K. Purushotorman· 2 shared M. K. McQueen· 2 shared P. J. Bond· 2 shared P. V. Raghuvamsi· 2 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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3 shared papersBiochemistry

F. Samsudin

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Author profile →

5 papers

Recent·Most cited

Isoform-specific C-terminal phosphorylation drives autoinhibition of Casein Kinase 1

R. L. Harold, N. K. Tulsian, R. Narasimamurthy, N. Yaitanes, M. G. A. Hernandez, H.-W. Lee, P. Crosby, S. Tripathi, D. M. Virshup, C. L. Partch

This study shows that isoform-specific phosphorylation in the C-terminal tail of CK1δ regulates its autoinhibition and affects circadian rhythms.

bioRxiv · Apr 24, 2023Biochemistry

Secreted dengue virus NS1 from infection is predominantly dimeric and in complex with high-density lipoprotein

B. L. A. Chew, A. Q. Ngoh, W. W. Phoo, W. K. K. Chan, S. Zheng, N. K. Tulsian, S. S. Lim, M. J. G. Weng, S. Watanabe, M. M. Choy, G. H. J. Low, E. E. Ooi, C. Ruedl, R. M. SOBOTA, S. G. Vasudevan, D. Luo

The paper determines the structure of secreted dengue virus NS1 from infected cells, showing it forms dimers complexed with HDL.

bioRxiv · Apr 6, 2022Microbiology

Mapping the allosteric effects that define functional activity of SARS-CoV-2 specific antibodies

N. K. Tulsian, P. V. Raghuvamsi, X. Qian, G. Yue, B. D/O Shunmuganathan, F. Samsudin, Y. H. Wong, L. Jianqing, K. Purushotorman, M. K. McQueen, B. Wang, J. Lescar, C.-I. Wang, G. Anand, P. J. Bond, P. A. MacAry

This study identifies site-specific allosteric effects in SARS-CoV-2 Spike protein induced by different neutralizing antibodies, revealing dynamic features that distinguish weak from strong neutralizers.

bioRxiv · Dec 27, 2021 · PreprintBiochemistry

Uncovering cryptic pockets in the SARS-CoV-2 spike glycoprotein

L. Zuzic, F. Samsudin, A. T. Shivgan, P. V. Raghuvamsi, J. K. Marzinek, A. Boags, C. Pedebos, N. K. Tulsian, J. Warwicker, P. MacAry, M. Crispin, S. Khalid, G. S. Anand, P. J. Bond

This study identifies a novel cryptic pocket on the SARS-CoV-2 spike protein using molecular dynamics simulations and validates its druggable potential through experimental methods.

bioRxiv · May 5, 2021Biophysics

SARS-CoV-2 S protein ACE2 interaction reveals novel allosteric targets

G. S. Anand, R. Palur, N. K. Tulsian, F. Samsudin, X. Qian, K. Purushotorman, G. Yue, M. K. McQueen, J. Lescar, P. Bond, P. A. McAry

The paper investigates how ACE2 binding to SARS-CoV-2 Spike protein allosterically affects proteolysis at distal cleavage sites and highlights potential therapeutic targets.

bioRxiv · Oct 13, 2020Biochemistry