Author

A. T. Shivgan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:virus· 2 Approach:comparative / phylogenetic analysis· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Approach:mechanistic / dynamical model· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1

Frequent Co-Authors

P. J. Bond· 4 shared J. K. Marzinek· 3 shared A. Krah· 2 shared C. S. Verma· 2 shared F. Samsudin· 2 shared L. Zuzic· 2 shared M. Crispin· 2 shared P. Matsudaira· 2 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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4 shared papersBiophysics

P. J. Bond

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Author profile →

4 papers

Recent·Most cited

A coarse-grained model of glycosaminoglycans for biomolecular simulation

A. T. Shivgan, J. K. Marzinek, A. Krah, P. Matsudaira, C. S. Verma, P. J. Bond

This paper develops a coarse-grained model for glycosaminoglycans compatible with Martini forcefields, enabling simulation of their conformational and thermodynamic properties.

bioRxiv · Oct 6, 2023Biophysics

Uncovering cryptic pockets in the SARS-CoV-2 spike glycoprotein

L. Zuzic, F. Samsudin, A. T. Shivgan, P. V. Raghuvamsi, J. K. Marzinek, A. Boags, C. Pedebos, N. K. Tulsian, J. Warwicker, P. MacAry, M. Crispin, S. Khalid, G. S. Anand, P. J. Bond

This study identifies a novel cryptic pocket on the SARS-CoV-2 spike protein using molecular dynamics simulations and validates its druggable potential through experimental methods.

bioRxiv · May 5, 2021Biophysics

Site-specific steric control of SARS-CoV-2 spike glycosylation

J. D. Allen, H. Chawla, F. Samsudin, L. Zuzic, A. T. Shivgan, Y. Watanabe, W.-T. He, S. Callaghan, G. Song, P. Yong, P. J. M. Brouwer, Y. Song, Y. Cai, H. M. E. Duyvesteyn, T. Malinauskas, , M. Crispin

The paper compares glycosylation patterns of recombinant SARS-CoV-2 spike proteins across labs with infectious virus S protein, finding conserved site-specific glycan maturation stalling linked to protein structure.

bioRxiv · Mar 8, 2021 · PreprintBiochemistry

Extending the Martini coarse-grained forcefield to N-glycans

A. T. Shivgan, J. K. Marzinek, R. G. Huber, A. Krah, R. H. Henchman, P. Matsudaira, C. S. Verma, P. J. Bond

This paper extends the Martini forcefield to model N-glycans by optimizing coarse-grained parameters and validating them against experimental data on lectin binding and solvation properties.

Journal of Chemical Information and Modeling · Jul 6, 2020Peer-reviewedBiophysics