Author

L.-L. Du

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4 Evolutionary Biology· 4 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:yeast· 5 Research Focus:chromatin & epigenetic regulation· 4 Research Focus:cell signaling & trafficking· 3 Organism:fungi (other)· 3 Research Focus:protein folding & dynamics· 3 Approach:statistical model· 3 Research Focus:cell type annotation· 2

Frequent Co-Authors

F. Suo· 5 shared M.-Q. Dong· 3 shared X.-M. Liu· 3 shared D.-D. Xu· 2 shared G.-C. Shao· 2 shared G.-S. Jia· 2 shared J.-X. Zheng· 2 shared S. Tusso· 2 shared

Activity by Year

2019-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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5 shared papersEvolutionary Biology

F. Suo

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Author profile →

9 papers

Recent·Most cited

Evolutionary modes of wtf meiotic driver genes in Schizosaccharomyces pombe

Y.-H. Xu, F. Suo, X.-R. Zhang, T.-Y. Du, Y. Hua, G.-S. Jia, J.-X. Zheng, L.-L. Du

The paper investigates the evolutionary mechanisms of wtf meiotic driver genes in S. pombe using long-read genome assemblies and identifies gene conversion and recombination events contributing to their diversity and persistence.

bioRxiv · May 30, 2024 · PreprintEvolutionary Biology

Ubiquitination-mediated Golgi-to-endosome sorting determines the toxin-antidote duality of wtf meiotic drivers

J.-X. Zheng, T.-Y. Du, G.-C. Shao, Z.-H. Ma, Z.-D. Jiang, W. Hu, F. Suo, W. He, M.-Q. Dong, L.-L. Du

The paper investigates how ubiquitination mediates the antagonistic duality of toxin and antidote proteins in fission yeast meiotic drivers, showing that ubiquitination promotes antidote localization to endosomes and neutralizes toxin activity.

bioRxiv · Jul 15, 2023 · PreprintCell Biology

The ortholog of human REEP1-4 is required for autophagosomal enclosure of ER-phagy/nucleophagy cargos in fission yeast

C.-X. Zou, Z.-H. Ma, Z. Jiang, Z.-Q. Pan, D.-D. Xu, F. Suo, G.-C. Shao, M.-Q. Dong, L.-L. Du

This study identifies Yep1 in fission yeast as essential for autophagosomal enclosure of ER-phagy and nucleophagy cargos, revealing its role in membrane shaping and cargo separation.

bioRxiv · Apr 24, 2023Cell Biology

The wtf meiotic driver gene family has unexpectedly persisted for over 100 million years

M. De Carvalho, G.-S. Jia, A. Nidamangala Srinivasa, R. B. Billmyre, Y.-H. Xu, J. J. Lange, I. M. Sabbarini, L.-L. Du, S. E. Zanders

This study identifies the persistence of the wtf meiotic driver gene family across four fission yeast species diverging over 100 million years ago, showing that active meiotic drive systems can persist long-term.

bioRxiv · Jun 24, 2022Evolutionary Biology

Reactivation of transposable elements following hybridization in fission yeast

S. Tusso, F. Suo, Y. Liang, L.-L. Du, J. B. W. Wolf

This study shows that hybridization in fission yeast reactivates transposable elements, with full-length elements increasing with genomic admixture.

bioRxiv · Aug 2, 2021Evolutionary Biology

Visual detection of binary, ternary, and quaternary protein-protein interactions in fission yeast by Pil1 co-tethering assay

Z.-Q. Yu, X.-M. Liu, D. Zhao, D.-D. Xu, L.-L. Du

The paper introduces a method to detect binary, ternary, and quaternary protein-protein interactions in fission yeast using a Pil1 co-tethering assay and demonstrates its application to characterize interactions in the Atg1 and PtdIns3K complexes.

bioRxiv · Apr 13, 2021Cell Biology

Molecular and structural mechanisms of ZZ domain-mediated cargo recognition by autophagy receptor Nbr1

Y.-Y. Wang, J. Zhang, X.-M. Liu, M.-Q. Dong, K. Ye, L.-L. Du

The paper identifies two new NVT cargos bound by Nbr1-ZZ1 and reveals the structural basis of ZZ domain-mediated cargo recognition in selective autophagy.

bioRxiv · Feb 7, 2021 · PreprintCell Biology

Intraspecific diversity of fission yeast mitochondrial genomes

Y.-T. Tao, F. Suo, S. Tusso, Y.-K. Wang, S. Huang, J. Wolf, L.-L. Du

This study analyzes the mitochondrial genome diversity of 192 S. pombe isolates, identifying 69 sequence types, two new introns, and two divergent clades, suggesting a split of ancestral lineages around 31 million generations ago.

bioRxiv · Jul 10, 2019Evolutionary Biology

Direct synthesis of EM-visible gold nanoparticles on genetically encoded tags for single-molecule visualization in cells

Z. Jiang, X. Jin, Y. Li, S. Liu, X.-M. Liu, Y.-Y. Wang, P. Zhao, X. Cai, Y. Liu, Y. Tang, X. Sun, Y. Liu, Y. Hu, M. Li, G. Cai, , W. He

This paper develops a method to directly synthesize EM-visible gold nanoparticles on genetically encoded tags for single-molecule visualization in cells, achieving high labeling efficiency in both prokaryotic and eukaryotic cells.

bioRxiv · Jan 17, 2019Biophysics