G. Cai

Mutation of phosphatidate phosphohydrolase genes confers broad-spectrum disease resistance in plants

The paper shows that mutating phosphatidate phosphohydrolase (PAH) genes in rice and Arabidopsis increases phosphatidic acid (PA) levels and broad-spectrum disease resistance.

Pharmacologic Inhibition of Ferroptosis Attenuates Experimental Abdominal Aortic Aneurysm Formation

This study shows that inhibiting ferroptosis with liproxstatin-1 reduces AAA formation by decreasing inflammation and aortic remodeling in mice.

Lipoxin A4/FPR2 signaling mitigates ferroptosis of alveolar epithelial cells via NRF2-dependent pathway during lung ischemia-reperfusion injury

This study shows that LxA4/FPR2 signaling reduces ferroptosis in alveolar epithelial cells via NRF2 activation, protecting against lung ischemia-reperfusion injury.

Cellular mechanotransduction of human osteoblasts in microgravity

This study investigates how microgravity affects human fetal osteoblasts by measuring cell mechanics and signaling changes in space compared to ground controls.

Potent and broadly neutralizing antibodies against sarbecoviruses induced by sequential COVID-19 vaccination

This study identifies potent and broadly neutralizing antibodies against SARS-CoV-2 and related sarbecoviruses from a vaccinated donor, showing their efficacy against multiple variants and providing insights for therapeutic development.

MerTK-dependent efferocytosis by monocytic-MDSCs mediates resolution of post-lung transplant injury

This study shows that MerTK-dependent efferocytosis by monocytic-MDSCs reduces post-lung transplant ischemia-reperfusion injury.

Enhanced neutralization of SARS-CoV-2 XBB sub-lineages and BA.2.86 by a tetravalent COVID-19 vaccine booster

This study evaluates the neutralization efficacy of a tetravalent vaccine booster against emerging SARS-CoV-2 variants, finding it induces higher neutralizing titers than breakthrough infection.

Matrix confinement modulates 3D spheroid sorting and burst-like collective migration

This study shows that matrix confinement affects 3D spheroid sorting and collective migration, with sorting dependent on cell-cell adhesion and matrix resistance.

Redefinition of archetypal phytoplankton-associated bacteria taxa based on globally distributed dinoflagellates and diatoms

The paper redefines phytoplankton-associated bacterial taxa at the genus level using data from diatoms and dinoflagellates, identifying core genera and their ecological roles in the phycosphere.

Neutralization of SARS-CoV-2 BQ.1.1 and XBB.1.5 by Breakthrough Infection Sera from Previous and Current Waves in China

This study assesses neutralization of SARS-CoV-2 Omicron subvariants by sera from different vaccination and breakthrough infection cohorts, finding that BQ.1.1 and XBB.1.5 show strong neutralization evasion.

Monitoring of urban ecological environment including air quality using satellite imagery

This study introduces a new remote sensing index for urban ecological monitoring by integrating air quality data with existing ecological factors, showing improved assessment in Beijing.

A portable and high-integrated 3D microfluidic chip for bacterial quantification and antibiotic susceptibility testing

This paper develops a portable 3D microfluidic chip for rapid single-cell antibiotic susceptibility testing and bacterial quantification, showing improved speed, sensitivity, and accuracy compared to traditional methods.

Rapid and Visible RPA-Cas12a fluorescence Assay for Accurate Detection of Zoonotic Dermatophytes

This paper develops a RPA-Cas12a fluorescence assay for rapid, accurate detection of zoonotic dermatophytes with high sensitivity and specificity.

A phosphorylation of RIPK3 kinase initiates an intracellular apoptotic pathway that promotes corpus luteum regression

This study shows that RIPK3 phosphorylation at S165/T166 switches its function from necroptosis to apoptosis, driving corpus luteum regression via PGF2-induced apoptosis.

Casein Kinase 1G2 Suppresses Necroptosis-Promoted Testis Aging by Inhibiting Receptor-Interacting Kinase 3

This study shows that CSNK1G2 inhibits RIP3-mediated necroptosis, reducing testis aging in mice and conserved in humans.

Continental-scale microbiome study reveals different environmental characteristics determining microbial richness and composition/quantity in hotel rooms

This study characterizes the microbial composition and environmental factors in hotel rooms across continents, finding associations between fungal and bacterial diversity, quantity, and environmental characteristics.

Mitochondrial Genome Sequence of Phytophthora sansomeana and Comparative Analysis of Phytophthora Mitochondrial Genomes

The paper sequences and annotates the mitochondrial genome of Phytophthora sansomeana and compares it with nine other Phytophthora species to identify genomic features and phylogenetic relationships.

Direct synthesis of EM-visible gold nanoparticles on genetically encoded tags for single-molecule visualization in cells

This paper develops a method to directly synthesize EM-visible gold nanoparticles on genetically encoded tags for single-molecule visualization in cells, achieving high labeling efficiency in both prokaryotic and eukaryotic cells.

Did a novel virus contribute to late blight epidemics?

This study identifies a novel RNA virus, PiRV-2, in Phytophthora infestans that enhances sporulation and virulence, suggesting it may contribute to late blight epidemics.

Generation of a novel growth-enhanced and reduced environmental impact transgenic pig strain

This study generates transgenic pigs expressing microbial enzymes to enhance feed digestion and reduce nutrient emissions, showing improved growth and lower environmental impact.