Y.-Y. Wang

Fish CDK2 recruits Dtx4 to degrade TBK1 through ubiquitination in the antiviral response

This study shows that fish CDK2 recruits Dtx4 to ubiquitinate and degrade TBK1, reducing IFN expression and enhancing antiviral resistance.

Transgenic female mice producing trans 10, cis 12-conjugated linoleic acid present excessive prostaglandin E2, adrenaline, corticosterone, glucagon, and FGF21

This study shows that transgenic female mice producing t10c12-CLA exhibit metabolic changes including increased prostaglandin E2, adrenaline, corticosterone, glucagon, and FGF21, indicating systemic hormonal effects.

Mechanism of glucocorticoid receptor activation regulated expression of thrombospondin-1

This study shows that glucocorticoid receptor activation increases TSP-1 expression through p38 MAPK and AGO-2 phosphorylation, and microRNA-1-3p inhibition in endothelial cells and platelets.

Molecular and structural mechanisms of ZZ domain-mediated cargo recognition by autophagy receptor Nbr1

The paper identifies two new NVT cargos bound by Nbr1-ZZ1 and reveals the structural basis of ZZ domain-mediated cargo recognition in selective autophagy.

Histone lysine crotonylation regulates cell-fate determination of neural stem/progenitor cells by activating bivalent promoters

This study identifies histone lysine crotonylation as an active promoter mark that regulates gene expression and neuronal differentiation in neural stem/progenitor cells.

ICOS enhances follicular T helper responses and deteriorates the pathogenic process of liver in mice infected with Schistosoma japonicum

This study shows that ICOS overexpression in mice worsens liver inflammation and fibrosis in Schistosoma japonicum infection by increasing Tfh cell frequency and altering cytokine responses.

Discovery of a novel coronavirus associated with the recent pneumonia outbreak in humans and its potential bat origin

This paper identifies and characterizes a novel coronavirus (nCoV-2019) causing a human pneumonia outbreak, showing its close genetic relationship to bat coronaviruses and its use of the ACE2 receptor for cell entry.

Direct synthesis of EM-visible gold nanoparticles on genetically encoded tags for single-molecule visualization in cells

This paper develops a method to directly synthesize EM-visible gold nanoparticles on genetically encoded tags for single-molecule visualization in cells, achieving high labeling efficiency in both prokaryotic and eukaryotic cells.

Antibody-mediated immobilization of virions in mucus

This study analyzes virion movement in mucus using single-particle tracking to show how antibodies immobilize virions through cooperative binding and entanglement with mucin.