Maria Greco

The paper identifies a hippocampal metabolic signature linked to mood and insulin signalling in depression, showing conserved effects across humans and mice.

The paper defines the developmental circuits and mechanisms underlying postnatal intestinal epithelial immune competency using single-cell multi-omics and spatial transcriptomics.

This study uses CRISPR-Cas genome editing to selectively inactivate JAK2 V617F mutations in patient cells, showing that heterozygous cells are not oncogene addicted while homozygous cells are eradicated, suggesting genome editing as a potential treatment for MPNs.

This study uses snRNA-seq and spatial transcriptomics to create a pediatric and adult brain cell atlas, identifying cell type-specific gene expression changes during human brain maturation.

The paper analyzes single-cell genomics and transcriptomics data from CRISPR-Cas9-edited human embryos to assess unintended editing outcomes and loss-of-heterozygosity.