Author

Laine Goudy

Gladstone Institutes

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 1 Immunology· 1 Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:benchmarking· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1 Organism:mouse· 1

Frequent Co-Authors

Alexander MarsoniD· 3 shared Luke A. GilbertiD· 3 shared Patrick D. HsuiD· 2 shared Silvana KonermanniD· 2 shared Aidan F. WintersiD· 1 shared Alex Dobin· 1 shared Alison FantoniD· 1 shared Andy Y. CheniD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersSynthetic Biology

Alexander MarsonORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Scalable probe-based single-cell transcriptional profiling for virtual cell perturbation mapping and synthetic biology phenotyping

Jason T. Swinderman, Po‐Yuan Tung, Aidan F. Winters, Laine Goudy, Caroline M. Wilson, Lexi R. Bounds, Noam Teyssier, Ayush Agrawal, Alex Dobin, Tony Hua, Hani Goodarzi, Felix Yi-Chung Feng, Alexander Marson, Dave P. Burke, Patrick D. Hsu, , Luke A. Gilbert

ProPer-seq is a cost-effective, barcode-free single-cell perturbation profiling method that enables scalable analysis of synthetic biology perturbations and reveals transcriptional control principles.

bioRxiv · Feb 5, 2026 · PreprintSynthetic Biology

Cis-Regulatory Element and Transcription Factor Circuitry Required for Cell-Type Specific Expression of FOXP3

Jennifer M. Umhoefer, Maya M. Arce, Sivakanthan Kasinathan, Sean Whalen, Rama Dajani, Sanjana Subramanya, Laine Goudy, Julia A. Belk, Royce W. Zhou, Minh T.N. Pham, Wenxi Zhang, Rosmely Hernandez, Carinna Tran, Nikhita Kirthivasan, Jacob W. Freimer, , Alexander Marson

The paper identifies cis-regulatory elements and transcription factors controlling FOXP3 expression in human Tregs and Tconvs, revealing mechanisms that restrict FOXP3 to Tregs in mice.

Immunity · Nov 13, 2025Peer-reviewedImmunology

Site-specific DNA insertion into the human genome with engineered recombinases

Alison Fanton, Liam J. Bartie, Juliana Q. Martins, Vincent Q. Tran, Laine Goudy, Courtney Kernick, Matthew G. Durrant, Jingyi Wei, Zev Armour-Garb, April Pawluk, Silvana Konermann, Alexander Marson, Luke A. Gilbert, Theodore L. Roth, Patrick D. Hsu

This study engineers recombinases to improve DNA insertion efficiency and specificity in human cells, achieving 53% integration and 97% genome-wide specificity.

Nature Biotechnology · Nov 6, 2025Peer-reviewedBioengineering