2'-O-Methyl-guanosine 3-base RNA fragments mediate essential natural TLR7/8 antagonism
Arwaf S. Alharbi, Sunil Sapkota, Zhikuan Zhang, Ruitao Jin, Erandi Rupasinghe, W. Samantha N. Jayasekara, Dingyi Yu, Mary Speir, Lorna E. Wilkinson‐White, Liza Cubeddu, Julia I. Ellyard, Refaya Rezwan, Daniel S. Wenholz, Alexandra L. McAllan, Rui Gao, , Michael Paul Gantier
The paper identifies 2'-O-methyl-guanosine RNA fragments as natural antagonists of TLR7/8, preventing auto-immunity by inhibiting TLR signaling.
Nature Immunology · Feb 10, 2026Peer-reviewedImmunology