Author

Frieda Balduin

German Center for Neurodegenerative Diseases

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Alexander von AppeniD· 1 shared Alvaro Dominguez‐Baquero· 1 shared Andrew G. NewmaniD· 1 shared Bilge AskiniD· 1 shared Bobby BeaumontiD· 1 shared Boglarka Krisztina Nagy-HerczegiD· 1 shared Bradley T. HymaniD· 1 shared Cagla Kilic· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperNeuroscience

Alexander von AppenORCID

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2 papers

Recent·Most cited

Utilizing a cell culture based novel cellular thermal shift assay to understand the isoform-dependent thermal stability of ApoE variants

Rosemary J. Jackson, Steven E. Dierksmeier, Maryam A. Nishtar, Jonah C Meltzer, Frieda Balduin, Bobby Beaumont, Zhanyun Fan, Eduard A. Sergienko, Steve Olson, Michael R Jackson, Bradley T. Hyman

The paper develops BiTSA, a bioluminescence-based thermal stability assay, to characterize isoform-dependent thermal stability of ApoE variants in living cells and confirms that ApoE4 is less stable than ApoE3 in native tissue.

bioRxiv · Jun 11, 2026 · PreprintNeuroscience

Tau modulates nuclear integrity, chromatin, and cholesterol synthesis genes via the nuclear envelope

Lisa Diez, Renata Ponce-Lina, Cagla Kilic, Rithika Sankar, Frieda Balduin, Cong Wang, Pia Grundschöttel, Koki Sakurai, Bilge Askin, Chiara Bordier, Tejaswini Karra, Katharina Tipp, Boglarka Krisztina Nagy-Herczeg, Maryam Mohamaddokht, Leandre M. Ravatt, , Susanne Wegmann

This study shows that increased somatodendritic Tau interacts with nuclear envelope proteins, causing nuclear damage and altering gene expression related to AD and tauopathies.

bioRxiv · Feb 14, 2026 · PreprintNeuroscience