Tau modulates nuclear integrity, chromatin, and cholesterol synthesis genes via the nuclear envelope
Lisa Diez, Renata Ponce-Lina, Cagla Kilic, Rithika Sankar, Frieda Balduin, Cong Wang, Pia Grundschöttel, Koki Sakurai, Bilge Askin, Chiara Bordier, Tejaswini Karra, Katharina Tipp, Boglarka Krisztina Nagy-Herczeg, Maryam Mohamaddokht, Leandre M. Ravatt, , Susanne Wegmann
This study shows that increased somatodendritic Tau interacts with nuclear envelope proteins, causing nuclear damage and altering gene expression related to AD and tauopathies.
bioRxiv · Feb 14, 2026 · PreprintNeuroscience