Glutamine antagonism suppresses tumor growth in adrenocortical carcinoma through inhibition of de novo nucleotide biosynthesis
Vasileios Chortis, Kleiton Silva Borges, Cong-Hui Yao, Claudio Henrique T. Ribeiro, Luís Fernando Peinado Nagano, Mesut Berber, Alessandro Prete, Lukáš Najdekr, Michail E. Klontzas, Andris Jankevics, Pedro Henrique Vendramini, Jean Lucas Kremer, Liam Kelley, Sathuwarman Raveenthiraraj, Alcides Euzebio Tavares Xavier, , David T. Breault
This study identifies glutamine antagonism as a therapeutic strategy for adrenocortical carcinoma by inhibiting de novo nucleotide biosynthesis and inducing DNA damage.
bioRxiv · Sep 28, 2025 · PreprintCancer Biology