Sathuwarman Raveenthiraraj

Glutamine antagonism suppresses tumor growth in adrenocortical carcinoma through inhibition of de novo nucleotide biosynthesis

This study identifies glutamine antagonism as a therapeutic strategy for adrenocortical carcinoma by inhibiting de novo nucleotide biosynthesis and inducing DNA damage.

Loss of WNT2B Increases Progression from Dysplasia to Colorectal Cancer

This study shows that loss of WNT2B promotes colorectal cancer progression in mouse models and is associated with poor patient survival in human samples.

WNT2B Deficiency Causes Increased Susceptibility to Colitis in Mice and Impairs Intestinal Epithelial Development in Humans

This study shows WNT2B deficiency in mice increases colitis susceptibility and impairs human intestinal development, with distinct effects in small intestine and colon.