Lin Chen

This study shows that ISGylation, induced by bacterial co-infection, promotes herpesvirus capsid assembly and replication by modifying viral proteins.

The paper shows c-Rel, an NF-κB family member, evolved unique DNA-binding properties in mammals, enhancing its ability to regulate Il12b and support immune complexity.

The paper shows transcript errors generate amyloid and prion-like proteins in human cells, linking DNA damage to aging and disease.

This paper introduces CTCC, a method using cryomilling to map chromatin interactions, showing it can generate global contact maps similar to Hi-C but with enhanced signal for stable inter-chromosomal contacts.

The paper uses Tethered Chromosome Conformation Capture to analyze adenovirus-host genome interactions in human lung fibroblasts, finding specific and non-random interactions enriched in active chromatin regions.