BCLAF1 links RNA splicing to ATF4-dependent metabolic adaptation in acute myeloid leukemia
Laura López-Hernández, Stephanie J. Crowley, Sara Cea-Sánchez, Ricardo de Arellano, Neetij Krishnan, Patrick Toolan-Kerr, Lynn S. White, Domenico Ignoti, Emily Soto-Hidalgo, Stefano Gustincich, Román González‐Prieto, Luca Pandolfini, Isaia Barbieri, Patricia Altea‐Manzano, Jeffrey A. Magee, , Gonzalo Millán-Zambrano
This study identifies BCLAF1 as a regulator linking RNA splicing to ATF4-dependent metabolic adaptation in AML, showing its role in sustaining leukemic cell survival and sensitivity to venetoclax.
bioRxiv · Jan 22, 2026 · PreprintCancer Biology