Author

Patrick Toolan-Kerr

Centro Andaluz de Biología Molecular y Medicina RegenerativaORCID 0000-0002-7970-649XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 2 Cancer Biology· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 3 Approach:experimental assay· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Assay:ChIP-seq· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Assay:DNA methylation· 1

Frequent Co-Authors

Luca PandolfiniiD· 3 shared Federica CapraroiD· 2 shared Gonzalo Millán-ZambranoiD· 2 shared Isaia BarbieriiD· 2 shared Jernej UleiD· 2 shared Laura López-HernándeziD· 2 shared Ricardo de ArellanoiD· 2 shared Adrien LégeriD· 1 shared

Activity by Year

2021-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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3 shared papersMolecular Biology

Luca PandolfiniORCID

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Author profile →

4 papers

Recent·Most cited

H3K37me1 couples transcription with DNA replication origin selection

Ricardo de Arellano, Patrick Toolan-Kerr, Iria Domínguez-García, Diego Polanco-Alonso, Laura López-Hernández, Simone Sidoli, Néstor García‐Rodríguez, Luca Pandolfini, Gonzalo Millán-Zambrano

This study identifies H3K37me1 as a histone modification that regulates DNA replication origin selection by limiting MCM2-7 association with transcribed chromatin.

bioRxiv · Jun 23, 2026 · PreprintMolecular Biology

BCLAF1 links RNA splicing to ATF4-dependent metabolic adaptation in acute myeloid leukemia

Laura López-Hernández, Stephanie J. Crowley, Sara Cea-Sánchez, Ricardo de Arellano, Neetij Krishnan, Patrick Toolan-Kerr, Lynn S. White, Domenico Ignoti, Emily Soto-Hidalgo, Stefano Gustincich, Román González‐Prieto, Luca Pandolfini, Isaia Barbieri, Patricia Altea‐Manzano, Jeffrey A. Magee, , Gonzalo Millán-Zambrano

This study identifies BCLAF1 as a regulator linking RNA splicing to ATF4-dependent metabolic adaptation in AML, showing its role in sustaining leukemic cell survival and sensitivity to venetoclax.

bioRxiv · Jan 22, 2026 · PreprintCancer Biology

RNA modifications detection by comparative Nanopore direct RNA sequencing

Adrien Léger, Paulo Amaral, Luca Pandolfini, Charlotte Capitanchik, Federica Capraro, Valentina Miano, Valentina Migliori, Patrick Toolan-Kerr, Theodora C. Sideri, Anton James Enright, Konstantinos Tzelepis, Folkert Jacobus van Werven, Nicholas M. Luscombe, Isaia Barbieri, Jernej Ule, , Tony Kouzarides

The paper introduces Nanocompore, a method to detect RNA modifications using Nanopore direct RNA sequencing, validated on human polyA+ RNAs and non-coding RNAs.

Nature Communications · Dec 10, 2021Peer-reviewedGenomics

An improved iCLIP protocol

Flora C. Y. Lee, Anob M. Chakrabarti, Heike Hänel, Elisa Monzón‐Casanova, Martina Hallegger, Cristina Militti, Federica Capraro, Christoph Sadée, Patrick Toolan-Kerr, Oscar G. Wilkins, Martin Turner, Julian König, Christopher R. Sibley, Jernej Ule

The paper introduces an improved CLIP protocol (iiCLIP) that produces more specific RNA binding site datasets compared to existing methods.

bioRxiv · Aug 27, 2021 · PreprintMolecular Biology