Luca Pandolfini

This study identifies TGS1 as a methyltransferase that modifies mRNAs encoding mitochondrial proteins in AML, promoting oxidative phosphorylation and cell survival, and shows its potential as a therapeutic target.

This study shows that recombination suppression through chromosomal rearrangements preceded fissiparous asexuality in planarians, reducing the costs of asexuality.

This study identifies H3K37me1 as a histone modification that regulates DNA replication origin selection by limiting MCM2-7 association with transcribed chromatin.

This study identifies BCLAF1 as a regulator linking RNA splicing to ATF4-dependent metabolic adaptation in AML, showing its role in sustaining leukemic cell survival and sensitivity to venetoclax.

The paper shows that an optimal ratio of inhibitory neurons is necessary for developing synchronized network activity in mouse cortical cultures.

The paper investigates METTL9's role in vertebrate neural development, finding its non-catalytic functions sustain neurogenesis through secretory pathway modulation.

This paper introduces CFC-seq and SALA to sequence non-poly(A) RNAs, identifies 39,425 novel transcriptional units, and reveals a genomic code governing enhancer RNA fate based on promoter architecture.

This paper presents chromosome-scale genome assemblies and regulatory element annotations for planarians, revealing conservation of regulatory regions despite rapid structural divergence.

The paper estimates hybridization load in Alpine ibex due to hybridization with domestic goats, finding increased loss-of-function mutations in hybrids compared to non-hybrids.

This study identifies SINEUP RNAs with Internal Ribosomal Entry Site (IRES) sequences as effector domains, enhancing translation of target mRNAs through both linear and circular transcripts.

This study shows Pgbd5 is essential for neuronal differentiation and radial migration in mouse corticogenesis, with effects on DNA double-strand breaks and gene expression.

The paper introduces Nanocompore, a method to detect RNA modifications using Nanopore direct RNA sequencing, validated on human polyA+ RNAs and non-coding RNAs.

The paper identifies miR-541 as an Eutherian-specific microRNA that regulates Satb2 translation during cortical development, revealing its role in timing neuronal identity.

This paper introduces a PCR-free NGS approach and software (DEAL) to accurately estimate antibody library diversity by accounting for sequencing errors.

This study shows miR-29 regulates iron homeostasis in the brain by reducing iron uptake, preventing excessive accumulation and age-related damage.