Jeffrey J. Bednarski

MLL3 and MLL4 sustain hematopoietic stem cell multipotency by opposing a B-cell default state

This study shows that MLL3 and MLL4 maintain hematopoietic stem cell multipotency by opposing a B-cell default state through distinct enhancer regulation mechanisms.

BCLAF1 links RNA splicing to ATF4-dependent metabolic adaptation in acute myeloid leukemia

This study identifies BCLAF1 as a regulator linking RNA splicing to ATF4-dependent metabolic adaptation in AML, showing its role in sustaining leukemic cell survival and sensitivity to venetoclax.

APOBEC3A drives metastasis of ovarian cancer by altering epithelial-to-mesenchymal transition

This study shows APOBEC3A promotes ovarian cancer metastasis by altering epithelial-to-mesenchymal transition in high-grade serous ovarian cancer.

The SMC5/6 complex is required for maintenance of genome integrity upon APOBEC3A-mediated replication stress

This study identifies the SMC5/6 complex as essential for genome stability in cells with active APOBEC3A, showing that its loss leads to increased DNA damage and replication stress.