S. Fujii

A high-fidelity in vitro model of the human intestinal epithelium

This paper develops an in vitro model of the human intestinal epithelium that closely mimics in vivo cell types using single-cell transcriptomics and a biomedical foundation model.

Membrane contact sites regulate vacuolar fission via sphingolipid metabolism

This study shows that deletion of tricalbins disrupts vacuolar morphology in yeast by altering sphingolipid metabolism through membrane contact sites.

Plastid anionic lipids are required for membrane development and protochlorophyllide synthesis in etioplasts

This study investigates the roles of anionic lipids PG and SQDG in etioplast development and Pchlide biosynthesis in Arabidopsis mutants.

Transcription-directed membrane association organizes the chloroplast nucleoid structure

The paper shows that transcription drives DNA organization in chloroplast nucleoids by tethering DNA to thylakoid membranes, creating an active core and less active periphery.

DNA repair and anti-cancer mechanisms in the longest-living mammal: the bowhead whale

This study investigates DNA repair mechanisms in bowhead whales, showing their high efficiency and accuracy in repairing DNA damage, which may explain their long lifespan without cancer.

In depth amino acid mutational analysis of the key interspecific incompatibility transmembrane factor Stigmatic Privacy 1

The paper identifies key amino acid residues in SPRI1 critical for its function in interspecific incompatibility in Arabidopsis thaliana.

A land plant specific VPS13 mediates polarized vesicle trafficking in germinating pollen

This study identifies AtVPS13a as a plant-specific protein required for directional vesicle trafficking during Arabidopsis pollen germination, linking it to pollen tube growth and cell wall deposition.

High-resolution map of plastid encoded polymerase binding patterns demonstrates a major role of transcription in chloroplast gene expression

The paper maps PEP binding patterns in Arabidopsis chloroplasts using ptChIP-seq, showing PEP's role in gene expression and its correlation with RNA accumulation.

Global monitoring of soil animal communities using a common methodology

The paper introduces a global collaborative network to standardize soil animal community monitoring and food web analysis across diverse ecosystems.

Globally invariant metabolism but density-diversity mismatch in springtails

The paper estimates global springtail biomass and density, finding similar energy use across latitudes but mismatch between diversity and density.

HSD11β1 promotes EMT-mediated breast cancer metastasis

This study identifies HSD11β1 as a promoter of breast cancer metastasis via EMT induction and shows that targeting HSD11β1 could suppress metastasis.

Phosphatidylglycerol synthesis facilitates plastid gene expression and light induction of nuclear photosynthetic genes

This study investigates how phosphatidylglycerol (PG) deficiency affects gene expression and plant growth in Arabidopsis, showing its role in nuclear-encoded photosynthesis genes and chloroplast development.

Crosstalk between repair pathways elicits Double-Strand Breaks in alkylated DNA: implications for the action of temozolomide

This study investigates how temozolomide induces DNA double-strand breaks through crosstalk between repair pathways in Xenopus egg extracts.

Biofilm Formation and Virulence of Shigella flexneri is Modulated by pH of Gastrointestinal Tract

This study shows that Shigella flexneri biofilm formation and virulence are influenced by pH, with acidic conditions promoting biofilm stability and virulence.

Prolonged impacts of past agriculture and overgrazing on soil fungal communities in restored forests

The paper examines how past agriculture and overgrazing affect soil fungal communities in restored forests, finding that fungal diversity is higher in reforested sites but community structure is more homogenized.

Targeting dormant ovarian cancer cells in vitro and in an in vivo model of platinum resistance

This study characterizes ovarian cancer spheroid phenotypes, identifies gene expression profiles linked to spheroid formation, and evaluates therapeutic responses of spheroids to various agents.