Neutralizing antibodies induced in immunized macaques recognize the CD4-binding site on an occluded-open HIV-1 envelope trimer
Z. Yang, K.-M. A. Dam, M. D. Bridges, M. A. G. Hoffmann, A. T. DeLaitsch, H. B. Gristick, A. Escolano, R. Gautam, M. A. Martin, M. Nussenzweig, W. Hubbell, P. J. Bjorkman
This study identifies two antibodies from immunized macaques that neutralize HIV-1 by targeting the CD4-binding site on an occluded-open Env trimer conformation.
bioRxiv · Nov 2, 2021Immunology