Author

R. Gautam

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4 Biophysics· 2 Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:host-pathogen & immune response· 4 Organism:human· 3 Organism:non-human primate· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Assay:imaging· 2

Frequent Co-Authors

A. Escolano· 3 shared H. B. Gristick· 3 shared M. A. Martin· 3 shared P. J. Bjorkman· 3 shared A. Mahadevan-Jansen· 2 shared E. D. Jansen· 2 shared G. A. Throckmorton· 2 shared M. C. Nussenzweig· 2 shared

Activity by Year

2018-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersImmunology

A. Escolano

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Interferon-γ signaling in eosinophilic esophagitis has implications for epithelial barrier function and programmed cell death.

M. Lal, C. M. Burk, R. Gautam, Z. Mrozek, T. Trachsel, J. T. Beers, M. C. Carroll, D. M. Morgan, A. B. Muir, W. G. Shreffler, M. A. Ruffner

This study investigates interferon-γ signaling in eosinophilic esophagitis, showing its impact on epithelial barrier function and apoptosis in esophageal epithelial cells.

bioRxiv · Jan 26, 2024 · PreprintImmunology

Neutralizing antibodies induced in immunized macaques recognize the CD4-binding site on an occluded-open HIV-1 envelope trimer

Z. Yang, K.-M. A. Dam, M. D. Bridges, M. A. G. Hoffmann, A. T. DeLaitsch, H. B. Gristick, A. Escolano, R. Gautam, M. A. Martin, M. Nussenzweig, W. Hubbell, P. J. Bjorkman

This study identifies two antibodies from immunized macaques that neutralize HIV-1 by targeting the CD4-binding site on an occluded-open Env trimer conformation.

bioRxiv · Nov 2, 2021Immunology

Visualizing the Role of Lipid Dynamics during Infrared Neural Stimulation with Hyperspectral Stimulated Raman Scattering Microscopy

W. R. Adams, R. Gautam, A. K. Locke, A. I. Borrachero-Conejo, B. R. Dollinger, G. A. Throckmorton, C. Duvall, E. D. Jansen, A. Mahadevan-Jansen

This study uses hyperspectral stimulated Raman scattering microscopy to observe lipid membrane dynamics during infrared neural stimulation in live neural cells, supporting the hypothesis that lipid packing order changes drive cell stimulation.

bioRxiv · May 24, 2021 · PreprintBiophysics

Antibody elicited by HIV-1 immunogen vaccination in macaques displaces Env fusion peptide and destroys a neutralizing epitope

M. E. Abernathy, H. B. Gristick, J. Vielmetter, J. R. Keeffe, P. N. Gnanapragasam, Y. E. Lee, A. Escolano, R. Gautam, M. S. Seaman, M. A. Martin, M. C. Nussenzweig, P. J. Bjorkman

This study identifies an off-target antibody that displaces the HIV-1 Env fusion peptide and blocks neutralizing epitopes, providing insights for vaccine design.

bioRxiv · Mar 17, 2021Immunology

A Broadly Neutralizing Macaque Monoclonal Antibody Against the HIV-1 V3-Glycan Patch

Z. Wang, C. O. Barnes, R. Gautam, J. C. Cetrulo Lorenzi, C. T. Mayer, T. Y. Oliveira, V. Ramos, M. Cipolla, K. M. Gordon, H. B. Gristick, A. P. West, Y. Nishimura, H. Raina, M. S. Seaman, A. Gazumyan, , M. C. Nussenzweig

This paper reports a broadly neutralizing monoclonal antibody from a macaque infected with SHIVAD8 that targets the V3-glycan patch of HIV-1 Env, showing neutralizing activity and protective efficacy in vivo.

bioRxiv · Aug 10, 2020Immunology

Multi-modal Nonlinear Optical and Thermal Imaging Platform for Label-Free Characterization of Biological Tissue

W. R. Adams, B. Mehl, E. Lieser, M. Wang, S. Patton, G. A. Throckmorton, J. L. Jenkins, J. B. Ford, R. Gautam, J. Brooker, E. D. Jansen, A. Mahadevan-Jansen

This paper introduces a multimodal imaging platform that combines nonlinear optical and thermal imaging to characterize biological tissues without labels.

bioRxiv · Apr 6, 2020Biophysics

Isolation and characterization of SARS-CoV-2 from the first US COVID-19 patient

J. Harcourt, A. Tamin, X. Lu, S. Kamili, S. Kumar Sakthivel, L. Wang, J. Murray, K. Queen, B. Lynch, B. Whitaker, Y. Tao, C. Paden, J. Zhang, Y. Li, A. Uehara, , N. J. Thornburg

The paper isolates and characterizes SARS-CoV-2 from the first US COVID-19 patient, showing high replication in Vero cells and depositing the strain for public use.

bioRxiv · Mar 2, 2020 · PreprintMicrobiology

Correlation of in vitro susceptibility based on MICs and SQLE mutations with clinical response to terbinafine in patients with tinea corporis/cruris

A. Khurana, A. Masih, A. Chowdhary, K. Sardana, S. Borker, A. Gupta, R. Gautam, P. Sharma, D. Jain

This study correlates in vitro susceptibility (MICs) and SQLE mutations with clinical response to terbinafine in tinea corporis/cruris patients, finding higher MICs and SQLE mutations associated with poorer outcomes.

bioRxiv · May 20, 2018Microbiology