A. K. Wheatley

Differential cross-reactivity to the influenza B virus haemagglutinin underpins lineage-specific susceptibility between birth cohorts

The paper shows that early life exposure to influenza B virus influences cross-reactivity and susceptibility to future isolates, explaining lineage-specific infection patterns across birth cohorts.

Monoclonal antibodies against human coronavirus NL63 spike

The paper characterises humoral responses and isolates neutralising antibodies against the NL63 coronavirus spike protein in healthy adults.

Rapid recall and de novo T cell responses during SARS-CoV-2 breakthrough infection

This study examines T cell responses during SARS-CoV-2 breakthrough infections, showing rapid recall of memory T cells and a correlation between CD8+ T cell activation and viral clearance.

The memory B cell response to influenza vaccination is impaired in older persons

This study shows that older adults have impaired memory B cell responses to influenza vaccination, characterized by reduced somatic hypermutation and positive selection in FCRL5+ atypical memory B cells.

Prime-boost protein subunit vaccines against SARS-CoV-2 are highly immunogenic in mice and macaques

This study evaluates S and RBD subunit vaccines in mice and macaques, finding S is more immunogenic and boosting enhances neutralizing titers.

Coformulation with tattoo ink for immunological assessment of vaccine immunogenicity in the draining lymph node

The paper develops a method to co-formulate vaccines with tattoo ink to identify vaccine-draining lymph nodes and assess antigen-specific immune responses in non-human primates.

Atypical B cells are a normal component of immune responses to vaccination and infection in humans

This study identifies atypical B cells as a normal part of immune responses to vaccination and infection in humans, showing they are present in both malaria-exposed and healthy individuals.

Design of nanoparticulate group 2 influenza hemagglutinin stem antigens that activate unmutated ancestor B cell receptors of broadly neutralizing antibody lineages

This study designs nanoparticle-based influenza HA stem antigens that activate unmutated B cell receptors of broadly neutralizing antibodies, potentially enabling cross-group immunity.