Author

M. B. Frieman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4 Microbiology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Research Focus:host-pathogen & immune response· 6 Research Focus:drug response / drug discovery· 4 Organism:mouse· 4 Organism:non-human primate· 2 Assay:proteomics· 2 Organism:human· 1 Assay:protein structure· 1

Frequent Co-Authors

C. Dillen· 3 shared A. D. Portnoff· 2 shared B. Zhou· 2 shared D. J. Dowling· 2 shared E. Nanishi· 2 shared G. Glenn· 2 shared G. Smith· 2 shared H. L. Hammond· 2 shared

Activity by Year

2018-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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3 shared papersImmunology

C. Dillen

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Reduced SARS-CoV-2 mRNA vaccine immunogenicity and protection in mice with diet-induced obesity and insulin resistance.

T. R. O'Meara, E. Nanishi, M. E. McGrath, S. Barman, D. Dong, C. Dillen, M. Menon, H.-S. Seo, S. Dhe-Paganon, R. K. Ernst, O. Levy, M. B. Frieman, D. J. Dowling

bioRxiv · Dec 7, 2022Immunology

SIRT-1 is required for release of enveloped picornaviruses

A. Jassey, J. Logue, S. Weston, M. A. Wagner, G. Galitska, K. A. Miller, M. B. Frieman, W. T. Jackson

This study shows SIRT-1 is essential for EV-D68 infection and enveloped virus release, independent of its deacetylase activity or autophagy.

bioRxiv · Aug 12, 2022Microbiology

Phage-like particle vaccines are highly immunogenic and protect against pathogenic coronavirus infection and disease

B. J. Davenport, A. Catala, S. M. Weston, R. M. Johnson, J. Ardunay, H. L. Hammond, C. Dillen, M. B. Frieman, C. E. Catalano, T. E. Morrison

This paper develops a phage-like particle vaccine platform that is immunogenic and protects against SARS-CoV-2 and MERS-CoV infection and disease.

bioRxiv · Nov 8, 2021Immunology

An adjuvanted SARS-CoV-2 RBD nanoparticle elicits neutralizing antibodies and fully protective immunity in aged mice

F. Borriello, E. Nanishi, H.-S. Seo, T. R. OMeara, M. E. McGrath, Y. Saito, R. E. Haupt, J. Chen, J. Diray-Arce, K. Song, A. Z. Xu, T. M. Caradonna, J. Feldman, B. M. Hauser, A. G. Schmidt, , O. Levy

This study identifies an adjuvanted SARS-CoV-2 RBD nanoparticle that induces neutralizing antibodies and full protection in aged mice.

bioRxiv · Sep 9, 2021 · PreprintImmunology

NVX-CoV2373 vaccine protects cynomolgus macaque upper and lower airways against SARS-CoV-2 challenge

M. Guebre-Xabier, N. Patel, J.-H. Tian, B. Zhou, S. Maciejewski, K. Lam, A. D. Portnoff, M. J. Massare, M. B. Frieman, P. A. Piedra, L. R. Ellingsworth, G. Glenn, G. Smith

This study evaluates the NVX-CoV2373 vaccine in cynomolgus macaques, showing it induces neutralizing antibodies and protects against SARS-CoV-2 infection in upper and lower airways.

bioRxiv · Aug 18, 2020Immunology

SARS-CoV-2 spike glycoprotein vaccine candidate NVX-CoV2373 elicits immunogenicity in baboons and protection in mice

J.-H. Tian, N. Patel, R. Haupt, H. Zhou, S. Weston, H. Hammond, J. Lague, A. D. Portnoff, J. Norton, M. Guebre-Xabier, B. Zhou, K. Jacobson, S. Maciejewski, R. Khatoon, M. Wisniewska, , G. Smith

This study evaluates the immunogenicity and protective efficacy of the NVX-CoV2373 SARS-CoV-2 vaccine in baboons and mice, showing strong immune responses and protection without enhanced disease.

bioRxiv · Jun 29, 2020Microbiology

Coronavirus S protein-induced fusion is blocked prior to hemifusion by Abl kinase inhibitors

J. Sisk, M. B. Frieman, C. E. Machamer

This study shows Abl kinase inhibitors block coronavirus S protein-induced fusion before hemifusion, reducing viral titers and syncytia formation in IBV.

bioRxiv · Jan 12, 2018Microbiology