Author

P. A. Piedra

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 7 Evolutionary Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Research Focus:host-pathogen & immune response· 7 Organism:human· 4 Research Focus:drug response / drug discovery· 3 Assay:proteomics· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:gene regulatory network inference· 2

Frequent Co-Authors

V. Avadhanula· 7 shared A. Rajan· 5 shared F. Stossi· 3 shared F.-A. Piedra· 3 shared K. L. Hoffman· 3 shared L. Aideyan· 3 shared T. McBride· 3 shared A. D. Portnoff· 2 shared

Activity by Year

2020-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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7 shared papersMicrobiology

V. Avadhanula

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Pediatric human nose organoids demonstrate greater susceptibility, epithelial responses, and cytotoxicity than adults during RSV infection.

G. M. Aloisio, D. Nagaraj, A. M. Murray, E. M. Schultz, T. McBride, L. Aideyan, E. G. Nicholson, D. Henke, L. Ferlic-Stark, A. Rajan, A. Kambal, H. Johnson, E. Mosa, F. Stossi, S. E. Blutt, , V. Avadhanula

This study compares RSV infection responses in pediatric and adult nose organoids, finding pediatric organoids show greater susceptibility, cytokine response, and cellular damage.

bioRxiv · Feb 1, 2024 · PreprintMicrobiology

Longitudinal host transcriptional responses to SARS-CoV-2 infection in adults with extremely high viral load

V. Avadhanula, C. J. Creighton, L. Ferlic-Stark, R. Sucgang, Y. Zhang, D. Nagaraj, E. G. Nicholson, A. Rajan, V. K. Menon, H. Doddapaneni, D. M. Muzny, G. A. Metcalf, S. J. J. Cregeen, K. L. Hoffman, R. A. Gibbs, , P. A. Piedra

The paper examines longitudinal transcriptional responses to SARS-CoV-2 infection in adults with varying viral loads, identifying gene expression patterns and host responses over time.

bioRxiv · May 24, 2023Microbiology

The efficiency of p27 peptide cleavage during in vitro respiratory syncytial virus (RSV) infection is cell line and RSV subtype dependent

W. Rezende, X. Ye, L. S. Angelo, A. Carisey, V. Avadhanula, P. A. Piedra

This study shows that p27 peptide cleavage efficiency of RSV F protein varies by RSV subtype and cell line, affecting pre-F conformation stability during temperature stress.

bioRxiv · Oct 17, 2022Microbiology

Diversity and Evolution of Computationally Predicted T Cell Epitopes against Human Respiratory Syncytial Virus

J. Chen, S. Tan, V. Avadhanula, L. Moise, P. A. Piedra, A. S. De Groot, J. Bahl

This study computationally predicts T cell epitopes in RSV proteins and finds divergent epitope patterns between RSV-A and RSV-B strains, suggesting vaccine updates may be needed for RSV-B.

bioRxiv · Jun 29, 2022Evolutionary Biology

The human nose organoid respiratory virus model: an ex-vivo human challenge model to study RSV and SARS-CoV-2 pathogenesis and evaluate therapeutics

A. Rajan, A. M. Weaver, G. M. Alosio, J. Jelinski, H. L. Johnson, S. F. Venable, T. McBride, L. Aideyan, F.-A. Piedra, X. Ye, E. Melicoff-Portillo, M. R. K. Yerramilli, X.-L. Zeng, M. A. Mancini, F. Stossi, , P. A. Piedra

This paper develops a non-invasive human nose organoid model to study RSV and SARS-CoV-2 infection and test therapeutics like palivizumab.

bioRxiv · Jul 28, 2021Microbiology

Multiple RSV strains infecting HEp-2 and A549 cells reveal cell line-dependent differences in resistance to RSV infection.

A. Rajan, F.-A. Piedra, L. Aideyan, T. McBride, M. J. Robertson, H. L. Johnson, G. M. Aloisio, D. M. Henke, C. Coarfa, F. Stossi, V. K. Menon, H. Doddapaneni, D. Muzny, S. J. Javornik Cregeen, K. L. Hoffman, , P. A. Piedra

The paper compares RSV infection in HEp-2 and A549 cells using four strains, finding subgroup-dependent gene expression differences and A549's greater antiviral response.

bioRxiv · Jun 15, 2021 · PreprintMicrobiology

NVX-CoV2373 vaccine protects cynomolgus macaque upper and lower airways against SARS-CoV-2 challenge

M. Guebre-Xabier, N. Patel, J.-H. Tian, B. Zhou, S. Maciejewski, K. Lam, A. D. Portnoff, M. J. Massare, M. B. Frieman, P. A. Piedra, L. R. Ellingsworth, G. Glenn, G. Smith

This study evaluates the NVX-CoV2373 vaccine in cynomolgus macaques, showing it induces neutralizing antibodies and protects against SARS-CoV-2 infection in upper and lower airways.

bioRxiv · Aug 18, 2020Immunology

Oligonucleotide capture sequencing of the SARS-CoV-2 genome and subgenomic fragments from COVID-19 individuals

H. V. Doddapaneni, S. J. Cregeen, R. Sucgang, Q. Meng, X. Qing, V. Avadhanula, H. Chao, V. Menon, E. Nicholson, D. Henke, F.-A. Piedra, A. Rajan, Z. Momin, K. Kottapalli, K. L. Hoffman, , R. A. Gibbs

This study develops an oligonucleotide capture sequencing method to generate SARS-CoV-2 genomic and transcriptome sequences from clinical samples, revealing differential transcriptional activity and ORF10 expression.

bioRxiv · Jul 27, 2020 · PreprintMicrobiology

SARS-CoV-2 spike glycoprotein vaccine candidate NVX-CoV2373 elicits immunogenicity in baboons and protection in mice

J.-H. Tian, N. Patel, R. Haupt, H. Zhou, S. Weston, H. Hammond, J. Lague, A. D. Portnoff, J. Norton, M. Guebre-Xabier, B. Zhou, K. Jacobson, S. Maciejewski, R. Khatoon, M. Wisniewska, , G. Smith

This study evaluates the immunogenicity and protective efficacy of the NVX-CoV2373 SARS-CoV-2 vaccine in baboons and mice, showing strong immune responses and protection without enhanced disease.

bioRxiv · Jun 29, 2020Microbiology