M. Bazzaro

The Microtubule Severing Protein UNC-45A Counteracts the Microtubule Straightening Effects of Taxol

This paper shows UNC-45A increases microtubule curvature and counteracts Taxol's straightening effects, suggesting a role in drug resistance.

Clinical Significance of the Stromatic Component in Ovarian Cancer: Quantity Over Quality in Outcome Prediction

This study shows that higher tumor-stroma proportion (TSP) in ovarian cancer is linked to worse patient outcomes, including shorter progression-free and overall survival, and increased chemoresistance.

GLS1 is a Protective Factor Rather than a Molecular Target in ARID1A-Mutated Ovarian Clear Cell Carcinoma

The paper investigates GLS1 expression in ARID1A-mutated ovarian clear cell carcinoma and finds it is not correlated with ARID1A loss and is associated with better clinical outcomes.

Targeting Mitochondrial Metabolism in Clear Cell Carcinoma of the Ovaries

This study shows that loss of ARID1A increases mitochondrial metabolism in OCCC and that inhibiting mitochondrial complex I improves survival in preclinical models.

UNC-45A Weakens and Breaks MT Lattice Independent of its Effect on Non-Muscle Myosin II

This study shows UNC-45A weakens and breaks microtubule lattices independently of its effect on non-muscle myosin II, with implications for disease treatment.

UNC-45A is preferentially expressed in epithelial cells and binds to and co-localizes with interphase MTs

This paper shows UNC-45A is preferentially expressed in epithelial cells and co-localizes with microtubules in interphase cells, independent of actin or myosin.