S. van der Werf

Sotrovimab retains activity against SARS-CoV-2 Omicron variant BQ.1.1 in a non-human primate model

This study shows Sotrovimab remains effective against SARS-CoV-2 BQ.1.1 in a non-human primate model, as measured by reduced viral replication.

Investigations on SARS-CoV-2 and other coronaviruses in mink farms in France at the end of the first year of COVID-19 pandemic

This study investigates SARS-CoV-2 and other viruses in French mink farms, finding high seropositivity and genetic diversity in one farm and co-circulation of other coronaviruses in others.

Enhanced neutralization escape to therapeutic monoclonal antibodies by SARS-CoV-2 Omicron sub-lineages

This study evaluates the neutralizing activity of monoclonal antibodies against SARS-CoV-2 Omicron sub-lineages and finds reduced efficacy against several variants.

Impact of variants of concern on SARS-CoV-2 viral dynamics in non-human primates.

This study examines how SARS-CoV-2 variants of concern affect viral dynamics in non-human primates, finding that most variants escape immune responses, with delta and omicron showing significant differences in viral production rates.

Potent Human Broadly SARS-CoV-2 Neutralizing IgA and IgG Antibodies Effective Against Omicron BA.1 and BA.2

The paper identifies potent broadly neutralizing IgA and IgG antibodies against SARS-CoV-2 variants, including Omicron BA.1 and BA.2, from memory B cells in convalescents.

A screening pipeline identifies a broad-spectrum inhibitor of bacterial AB toxins with cross protection against influenza A virus H1N1 and SARS-CoV-2

Immunization with synthetic SARS-CoV-2 S glycoprotein virus-like particles protects Macaques from infection

This study develops a synthetic SARS-CoV-2 S glycoprotein virus-like particle vaccine that protects macaques from infection through strong antibody and T cell responses.

A mouse-adapted SARS-CoV-2 strain replicating in standard laboratory mice.

This study develops a mouse-adapted SARS-CoV-2 strain that replicates efficiently in standard mice and causes mild to moderate lung disease.

Identification of DAXX As A Restriction Factor Of SARS-CoV-2 Through A CRISPR/Cas9 Screen

The paper identifies DAXX as a restriction factor of SARS-CoV-2 through a CRISPR/Cas9 screen, showing it limits viral replication independently of SUMOylation.

Variants with the N501Y mutation extend SARS-CoV-2 host range to mice, with contact transmission

The paper shows that SARS-CoV-2 variants with the N501Y mutation can infect and transmit to mice, suggesting potential for rodent reservoirs.

Sensitivity of infectious SARS-CoV-2 B.1.1.7 and B.1.351 variants to neutralizing antibodies

This study assesses the neutralization sensitivity of SARS-CoV-2 B.1.1.7 and B.1.351 variants compared to D614G using sera and nasal swabs, finding reduced efficacy against B.1.351 in some convalescent and vaccinated individuals.

Absence of SARS-CoV-2 infection in cats and dogs in close contact with a cluster of COVID-19 patients in a veterinary campus

The paper tests domestic pets for SARS-CoV-2 infection after their owners were infected, finding no evidence of infection in the pets.

Syncytia formation by SARS-CoV-2 infected cells

This study shows SARS-CoV-2 infected cells form syncytia via Spike protein-mediated fusion, regulated by IFITMs and TMPRSS2.