Author

R. Copin

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Biophysics· 1 Evolutionary Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 5 Organism:human· 3 Approach:statistical model· 2 Research Focus:chromatin & epigenetic regulation· 1 Assay:cryo-EM· 1 Assay:imaging· 1 Assay:metagenomics· 1

Frequent Co-Authors

A. Baum· 5 shared C. A. Kyratsous· 4 shared G. S. Atwal· 3 shared A. J. Murphy· 2 shared A. Oyejide· 2 shared A. Zhou· 2 shared B. Klaffke· 2 shared C. Bartley· 2 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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5 shared papersMicrobiology

A. Baum

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Structure of the Inmazeb cocktail and resistance to escape against Ebola virus

V. Rayaprolu, B. Fulton, A. Rafique, E. Arturo, D. Williams, C. Hariharan, H. Callaway, A. Parvate, S. L. Schendel, D. Parekh, S. Hui, K. Shaffer, K. E. Pascal, E. Wloga, S. Giordano, , E. O. Saphire

The paper presents the cryoEM structure of the Inmazeb cocktail in complex with Ebola virus glycoprotein, showing how the combination prevents escape mutations better than monotherapy.

bioRxiv · Oct 11, 2022Biophysics

Clostridia isolated from helminth-colonized humans promote hatching of Trichuris muris

S. Sargsian, Z. Chen, S. C. Lee, A. Robertson, J. Sproch, J. C. Devlin, M. Z. Tee, Y. X. Er, R. Copin, A. Heguy, A. Pironti, V. J. Torres, K. V. Ruggles, Y. A. L. Lim, P. Loke, K. Cadwell

The paper isolates and characterizes Clostridia from helminth-colonized humans, showing they promote hatching of Trichuris muris eggs.

bioRxiv · Feb 10, 2022Microbiology

Viral population genomics reveals host and infectivity impact on SARS-CoV-2 adaptive landscape

K. Gayvert, R. Copin, S. McKay, I. Setliff, W. K. Lim, A. Baum, C. A. Kyratsous, G. S. Atwal

The paper analyzes SARS-CoV-2 genomic diversity to identify sites under selection, showing purifying selection dominates with some diversifying pressure, particularly in the spike protein and T cell epitopes.

bioRxiv · Dec 30, 2021 · PreprintEvolutionary Biology

REGEN-COV protects against viral escape in preclinical and human studies

R. Copin, A. Baum, E. Wloga, K. E. Pascal, S. Giordano, B. O. Fulton, A. Zhou, N. Negron, K. Lanza, N. Chan, A. Coppola, J. Chiu, M. Ni, G. S. Atwal, A. Romero Hernandez, , C. A. Kyratsous

This study shows that REGEN-COV, a combination of non-competing antibodies, provides broad coverage against SARS-CoV-2 variants and prevents the emergence of new variants in clinical and preclinical settings.

bioRxiv · Mar 10, 2021 · PreprintMicrobiology

REGN-COV2 antibody cocktail prevents and treats SARS-CoV-2 infection in rhesus macaques and hamsters

A. Baum, R. Copin, D. Ajithdoss, A. Zhou, K. Lanza, N. Negron, M. Ni, Y. Wei, G. S. Atwal, A. Oyejide, Y. Goez-Gazi, J. Dutton, E. Clemmons, H. M. Staples, C. Bartley, , C. A. Kyratsous

This study evaluates the efficacy of the REGN-COV2 antibody cocktail in preventing and treating SARS-CoV-2 infection in rhesus macaques and hamsters, showing reduced virus load and pathological effects.

bioRxiv · Aug 2, 2020Microbiology

SARS-CoV-2 infection leads to acute infection with dynamic cellular and inflammatory flux in the lung that varies across nonhuman primate species

D. K. Singh, S. R. Ganatra, B. Singh, J. Cole, K. J. Alfson, E. Clemmons, M. Gazi, O. Gonzalez, R. Escabedo, T.-H. Lee, A. Chatterjee, Y. Goez-Gazi, R. Sharan, R. Thippeshappa, M. Gough, , M

This study compares SARS-CoV-2 infection in three nonhuman primate species, showing varied disease progression and immune responses.

bioRxiv · Jun 5, 2020Immunology