M. C. Krishna

Evofosfamide and Gemcitabine Act Synergistically in Pancreatic Cancer Xenografts by Dual Action on Tumor Vasculature and Inhibition of Homologous Recombination DNA Repair

This study shows that evofosfamide and gemcitabine work together in pancreatic cancer xenografts by improving tumor oxygenation and inhibiting DNA repair, with effects varying by tumor type.

Evaluation of a deuterated triarylmethyl spin probe for in vivo R2*-based EPR oximetric imaging with enhanced dynamic range

This study compares two spin probes for oxygen measurement in vivo, finding Ox071 more sensitive and capable of a broader pO2 range.

PEGPH20, a PEGylated Human Hyaluronidase, Induces Radiosensitization by Reoxygenation In Pancreatic Cancer Xenografts. A Molecular Imaging Study

This study shows PEGPH20 improves radiation therapy efficacy in pancreatic cancer tumors with high hyaluronan by increasing oxygenation, as measured by multiple imaging techniques.

Detecting Early Response to Immune Checkpoint Blockade by Multimodal Molecular Imaging

This study uses multimodal imaging to detect early response to immune checkpoint blockade therapy in tumor models, identifying imaging biomarkers for treatment assessment.

In vivo deuterated water labeling allows tumor visualization via deuterium magnetic resonance spectroscopic imaging of cholesterol

Reoxygenation after Evofosfamide Treatment in Pancreatic Ductal Adenocarcinoma Xenografts is due to Decreased Oxygen Consumption and not Increased Oxygen Supply

This study shows evofosfamide treatment reduces tumor hypoxia by decreasing oxygen consumption, not increasing oxygen supply, using pO2 imaging in xenograft models.

Glycolytic metabolism of pathogenic T cells enables early detection of GvHD by 13C-MRI

This study uses 13C-MRI to detect early glycolytic activity in T cells, enabling non-invasive GvHD detection before symptoms appear.

Trehalose as an alternative to glycerol as a glassing agent for in vivo DNP MRI

This study compares trehalose and glycerol as glassing agents in DNP MRI, finding trehalose provides faster polarization with similar effectiveness and fewer metabolic perturbations.

Distinguishing Closely Related Pancreatic Cancer Subtypes In Vivo by 13C Glucose MRI without Hyperpolarization

The paper distinguishes closely related pancreatic cancer subtypes in vivo using 13C glucose MRI without hyperpolarization by detecting metabolic differences through tensor decomposition.