Author

W. M. Linehan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Biochemistry· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Assay:proteomics· 4 Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Approach:deep learning· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Assay:imaging· 1

Frequent Co-Authors

D. W. Bak· 3 shared E. Weerapana· 3 shared J. L. Meier· 3 shared M. Perez· 2 shared S. E. Bergholtz· 2 shared A. Alpsoy· 1 shared A. Bavari· 1 shared A. L. Thorpe· 1 shared

Activity by Year

2018-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersCancer Biology

D. W. Bak

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Conditional covalent lethality driven by oncometabolite accumulation

M. Perez, K. D. Nance, D. W. Bak, S. T. Gamage, S. S. Najera, A. N. Conte, W. M. Linehan, E. Weerapana, J. L. Meier

The paper identifies a covalent small molecule, MP-1, that exhibits FH-dependent cytotoxicity in HLRCC by targeting cysteine residues, including in TRMT1, and shows TRMT1 overexpression can rescue tRNA methylation inhibition.

bioRxiv · Apr 26, 2022Biochemistry

Heterogeneous adaptation of cysteine reactivity to a covalent oncometabolite

M. Perez, D. W. Bak, S. E. Bergholtz, D. R. Crooks, Y. Yang, W. M. Linehan, E. Weerapana, J. L. Meier

The paper reports a chemoproteomic analysis of cysteine reactivity in HLRCC cells upon FH rescue, revealing transcriptional and posttranslational regulation of cysteine residues.

bioRxiv · Jun 25, 2020Cancer Biology

Glycolytic metabolism of pathogenic T cells enables early detection of GvHD by 13C-MRI

J. C. Assmann, D. E. Farthing, K. Saito, N. Maglakelidze, B. Oliver, K. A. Warrick, C. Sourbier, C. J. Ricketts, T. J. Meyer, S. Z. Pavletic, W. M. Linehan, M. C. Krishna, R. E. Gress, N. P. Buxbaum

This study uses 13C-MRI to detect early glycolytic activity in T cells, enabling non-invasive GvHD detection before symptoms appear.

bioRxiv · Mar 16, 2020Immunology

A chemoproteomic portrait of the oncometabolite fumarate

R. A. Kulkarni, D. W. Bak, D. Wei, S. E. Bergholtz, C. A. Briney, J. H. Shrimp, A. L. Thorpe, A. Bavari, A. Alpsoy, M. Levy, L. Florens, M. P. Washburn, E. C. Dykhuizen, N. Frizzell, E. Weerapana, , J. L. Meier

This study maps fumarate's covalent targets using chemoproteomic probes and identifies cysteine residues affected by fumarate or FH mutations in HLRCC cells.

bioRxiv · Mar 22, 2018Cancer Biology