Author

G. G. van Dooren

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5 Biochemistry· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Research Focus:host-pathogen & immune response· 5 Organism:human· 2 Organism:plant (other)· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

E. Rajendran· 4 shared K. Kirk· 3 shared B. Steinhoefel· 2 shared C. Spry· 2 shared E. T. Tjhin· 2 shared J. A. Hayward· 2 shared K. J. Saliba· 2 shared S. M. Zwahlen· 2 shared

Activity by Year

2018-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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4 shared papersMicrobiology

E. Rajendran

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Author profile →

7 papers

Recent·Most cited

A screen of drug-like molecules identifies chemically diverse electron transport chain inhibitors in apicomplexan parasites

J. A. Hayward, F. V. Makota, D. Cihalova, E. Rajendran, S. M. Zwahlen, L. Shuttleworth, U. Wiedemann, C. Spry, K. J. Saliba, A. G. Maier, G. G. van Dooren

The paper screens drug-like molecules to identify new electron transport chain inhibitors in apicomplexan parasites, finding chemically diverse compounds effective against resistant strains.

bioRxiv · Feb 13, 2022Microbiology

Generation and characterisation of P. falciparum parasites with a G358S mutation in the PfATP4 Na+ pump and clinically relevant levels of resistance to some PfATP4 inhibitors

D. Qiu, J. V. Pei, J. E. O. Rosling, D. Li, Y. Xue, J. S. Penington, K. Kümpornsin, Y. T. V. Aw, J. Y. H. Aw, H. Hasemer, A. S. M. Dennis, M. C. Ridgway, A. T. Papenfuss, M. C. S. Lee, G. G. van Dooren, , A. M. Lehane

This paper shows that a G358S mutation in PfATP4 confers clinically relevant resistance to cipargamin and (+)-SJ733 in P. falciparum parasites.

bioRxiv · Jan 11, 2022Microbiology

Coordinated Action of Multiple Transporters in the Acquisition of Essential Cationic Amino Acids by the Intracellular Parasite Toxoplasma gondii

S. J. Fairweather, E. Rajendran, M. Blume, K. Javed, B. Steinhoefel, M. J. McConville, K. Kirk, S. Broer, G. G. van Dooren

This study identifies TgApiAT6-1 as a second arginine transporter in Toxoplasma gondii, showing it mediates both lysine and arginine uptake and is essential for parasite proliferation.

bioRxiv · Jun 25, 2021Microbiology

A novel heteromeric pantothenate kinase complex in apicomplexan parasites

E. T. Tjhin, V. M. Howieson, C. Spry, G. G. van Dooren, K. J. Saliba

The paper identifies heteromeric pantothenate kinase complexes in Plasmodium falciparum and Toxoplasma gondii, showing that PanK1 and PanK2 form functional complexes with Pf14-3-3I and are essential for parasite proliferation.

bioRxiv · Mar 16, 2021Biochemistry

Divergent features of the coenzyme Q:cytochrome c oxidoreductase complex in Toxoplasma gondii parasites

J. A. Hayward, E. Rajendran, S. M. Zwahlen, P. Faou, G. G. van Dooren

This study identifies novel and divergent components of the coenzyme Q:cytochrome c oxidoreductase complex in Toxoplasma gondii, revealing differences from mammalian Complex III.

bioRxiv · Aug 18, 2020Microbiology

Substrate-mediated regulation of the arginine transporter of Toxoplasma gondii

E. Rajendran, M. Clark, C. Goulart, B. Steinhoefel, E. T. Tjhin, N. C. Smith, K. Kirk, G. G. van Dooren

This study shows that Toxoplasma gondii regulates its arginine transporter TgApiAT1 expression in response to arginine availability, mediated by a uORF in the transcript.

bioRxiv · Oct 9, 2019Microbiology

Calcium negatively regulates secretion from dense granules in Toxoplasma gondii.

N. J. Katris, G. I. McFadden, G. G. van Dooren, R. F. Waller

This study shows that calcium negatively regulates dense granule exocytosis in Toxoplasma gondii, dependent on calcium-dependent protein kinases TgCDPK1 and TgCDPK3.

bioRxiv · Aug 7, 2018Cell Biology