Author

N. R. Sexton

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:mouse· 5 Research Focus:host-pathogen & immune response· 4 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

G. D. Ebel· 3 shared M. R. Denison· 3 shared X. Lu· 3 shared B. J. Geiss· 2 shared E. C. Smith· 2 shared J. B. Case· 2 shared K. W. Graepel· 2 shared A. Fagre· 1 shared

Activity by Year

2017-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersMicrobiology

G. D. Ebel

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Durable antibody responses in staff at two long-term care facilities, during and post SARS-CoV-2 outbreaks

E. Gallichotte, M. Nehring, M. C. Young, S. Pugh, N. R. Sexton, E. Fitzmeyer, K. M. Quicke, M. Richardson, K. L. Pabilonia, N. Ehrhart, S. VandeWoude, G. D. Ebel

The paper examines antibody responses in long-term care facility staff during and after SARS-CoV-2 outbreaks, finding durable neutralizing antibodies and potential herd immunity.

bioRxiv · May 4, 2021Immunology

A Hyperactive Kunjin Virus NS3 Helicase Mutant Demonstrates Increased Dissemination and Mortality in Mosquitoes

K. E. Du Pont, N. R. Sexton, M. McCullagh, G. D. Ebel, B. J. Geiss

This study investigates the role of NS3 Motif V mutations in Kunjin virus replication and pathogenesis, finding that S411A mutant increases viral dissemination and mortality in mosquitoes.

Journal of Virology · Sep 15, 2020Peer-reviewedMicrobiology

SARS-CoV-2 infection, neuropathogenesis and transmission among deer mice: Implications for reverse zoonosis to New World rodents

A. Fagre, J. Lewis, M. Eckley, S. Zhan, S. M. Rocha, N. R. Sexton, B. Burke, B. J. Geiss, O. Peersen, R. Kading, J. Rovnak, G. D. Ebel, R. B. Tjalkens, T. Aboellail, T. Schountz

This study infects deer mice with SARS-CoV-2, showing robust replication and potential for natural transmission, with a new spike protein mutation emerging during in vivo passage.

bioRxiv · Aug 7, 2020Microbiology

Fitness barriers limit reversion of a proofreading-deficient coronavirus

K. W. Graepel, M. L. Agostini, X. Lu, N. R. Sexton, M. R. Denison

This study shows that reversion of a proofreading-deficient coronavirus (ExoN-AA) is hindered by fitness barriers, as compensatory mutations outside the ExoN motif I are more advantageous than partial reversion.

bioRxiv · Apr 26, 2019Microbiology

Mouse hepatitis virus nsp14 exoribonuclease activity is required for resistance to innate immunity

J. B. Case, Y. Li, R. Elliott, X. Lu, K. W. Graepel, N. R. Sexton, E. C. Smith, S. R. Weiss, M. R. Denison

This study shows that MHV nsp14 exoribonuclease activity is necessary for resisting innate immunity by affecting viral RNA and modifications.

bioRxiv · Aug 29, 2017Microbiology

Proofreading-deficient coronaviruses adapt over long-term passage for increased fidelity and fitness without reversion of exoribonuclease-inactivating mutations

K. Graepel, X. Lu, J. B. Case, N. R. Sexton, E. C. Smith, M. R. Denison

bioRxiv · Aug 11, 2017Microbiology