H. Moch

Heterogeneous and Novel Transcript Expression in Single Cells of Patient-Derived ccRCC Organoids

This study uses single-cell long-read sequencing to analyze transcriptomes of ccRCC organoids, identifying novel transcripts and highlighting cell-specific alternative splicing events.

Multi-resolution deep learning characterizestertiary lymphoid structures in solid tumors

This paper introduces HookNet-TLS, a deep learning model for automated TLS quantification in cancer pathology slides, achieving human-level performance and prognostic associations.

A statistical test for clonal exclusivity in tumour evolution

This paper introduces a statistical test, GeneAccord, to identify clonally exclusive gene pairs in tumours and applies it to AML data, finding 6 exclusive and 2 co-occurring pairs.

Spatial distribution of private gene mutations in clear cell renal cell carcinoma

The paper analyzes intra-tumour heterogeneity and subclonal mutations in clear cell renal cell carcinoma using multi-regional sequencing, finding that most tumours harbor private mutations and clonally exclusive pathway pairs.

Blunted Fas signaling favors RIPK1-driven neutrophil necroptosis in critically ill COVID-19 patients

The paper shows that in critically ill COVID-19 patients, dysregulated Fas signaling leads to increased RIPK1-driven necroptosis in neutrophils, contributing to disease severity.

SF3B1 promotes tumor malignancy through splicing-independent co-activation of HIF1α

This study shows SF3B1 promotes tumor malignancy by co-activating HIF1α through a splicing-independent mechanism, enhancing hypoxia response element binding and target gene expression.

Dual Functions of SPOP and ERG Dictate Androgen Therapy Responses in Prostate Cancer

This study shows that SPOP and ERG mutations in prostate cancer have opposing effects on androgen receptor signaling and therapy response.

SAMHD1 mutations in mantle cell lymphoma are recurrent and confer in vitro resistance to nucleoside analogues

CD39+PD-1+CD8+ T cells mediate metastatic dormancy in breast cancer

This study identifies CD39+PD-1+CD8+ T cells as critical for metastatic dormancy in breast cancer, showing their role in suppressing tumor growth and their potential as a biomarker and immunotherapy target.

Highly multiplexed molecular and cellular mapping of breast cancer tissue in three dimensions using mass tomography.

This study introduces mass tomography to enable 3D analysis of breast cancer tissue using imaging mass cytometry, revealing spatial heterogeneity and micro-invasion dynamics.

The Genomic Landscape of Prostate Cancer Brain Metastases

This study identifies genomic alterations in prostate cancer brain metastases, highlighting mutations in NF1 and RICTOR and DNA homologous repair defects as potential drivers.

The landscape of viral associations in human cancers

The paper systematically investigates viral associations in human cancers using whole-genome and transcriptome data from 2,656 donors, revealing prevalence of known tumor-associated viruses and their genomic impacts.