Author

T. Shibahara

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Immunology· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Research Focus:host-pathogen & immune response· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

A. Kumanogoh· 2 shared A. Okamoto· 1 shared B. A. Martin· 1 shared B. Temizoz· 1 shared C. Coban· 1 shared C. H. Contag· 1 shared C. V. Maduka· 1 shared C. Wada· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

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2 shared papersImmunology

A. Kumanogoh

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

5,6-dimethylxanthenone-4-acetic acid (DMXAA), a Partial STING Agonist, Competes for Human STING Activation

B. Temizoz, T. Shibahara, K. Hioki, T. Hayashi, K. Kobiyama, M. S. J. Lee, N. Surucu, E. Sag, A. Kumanogoh, M. Yamamoto, M. Gursel, S. Ozen, E. Kuroda, C. Coban, K. J. Ishii

This paper investigates DMXAA's partial STING agonist activity and develops HHMX, a derivative that antagonizes STING-mediated immune responses in both humans and mice.

bioRxiv · Dec 7, 2023 · PreprintImmunology

Flavinated SDHA Underlies the Change in Intrinsic Optical Properties of Oral Cancers

T. Marumo, C. V. Maduka, E. Ural, E. H. Apu, S.-J. Chung, N. S. van den Berg, Q. Zhou, B. A. Martin, E. L. Rosenthal, T. Shibahara, C. H. Contag

The paper identifies flavinated SDHA as responsible for altered autofluorescence in oral cancer cells, linking it to metabolic changes and potential diagnostic and therapeutic targets.

bioRxiv · Jul 30, 2023Cancer Biology

Cellular adhesion is a controlling factor in neutrophil extracellular trap formation induced by antineutrophil cytoplasmic antibodies

P. M. Lelliott, M. Nishide, N. Pavillon, Y. Okita, T. Shibahara, Y. Mizuno, H. Yoshimura, S. Obata, A. Kumanogoh, N. I. Smith

This study shows that neutrophil adhesion is essential for ANCA-induced NET formation and that targeting adhesion factors could prevent NET-mediated damage in AAV.

bioRxiv · Oct 19, 2021 · PreprintImmunology

Deep learning generates custom-made logistic regression models for explaining how breast cancer subtypes are classified

T. Shibahara, C. Wada, Y. Yamashita, K. Fujita, M. Sato, A. Okamoto, Y. Ono

The paper develops an explainable deep learning model to generate logistic regression models for breast cancer subtype classification, showing its utility in identifying gene-subtype relationships.

bioRxiv · May 10, 2021 · PreprintCancer Biology

Capsular polysaccharide switching in Streptococcus suis modulates host cell interactions and virulence

M. Okura, J.-P. Auger, T. Shibahara, G. Goyette-Desjardins, M.-R. Van Calsteren, F. Maruyama, M. Kawai, M. Osaki, M. Segura, M. Gottschalk, D. Takamatsu

This study shows that serotype switching in Streptococcus suis can differentially affect host cell interactions and virulence, with some serotypes increasing or decreasing pathogenicity.

bioRxiv · Oct 12, 2020Microbiology