R. Ito

Structure-activity relationships of coumarin and its analogs and mechanistic insights into germination inhibition by coumarin

This study investigates coumarin's structure-activity relationships and its mechanism of germination inhibition in two plant species, identifying key structural features and gene targets.

Atlas of Cynomolgus Macaque Hematopoiesis

The paper develops a single-cell transcriptomic map of cynomolgus macaque hematopoietic stem cells and progenitors, revealing molecular differences from humans and a direct differentiation pathway to megakaryocyte lineages.

NFYA promotes the anti-tumor effects of gluconeogenesis in hepatocellular carcinoma through the regulation of PCK1 expression

This study shows that NFYAv2 promotes anti-tumor effects in HCC by upregulating PCK1, leading to increased ROS and energy crisis, and suggests it as a potential therapeutic target.

NPC1L1 inhibition disturbs lipid trafficking and induces large lipid droplet formation in intestinal absorptive epithelial cells

This study shows that NPC1L1 inhibition reduces chylomicron assembly and secretion in intestinal cells by limiting cholesterol availability, leading to large lipid droplet formation.

Distinct chemotactic behavior in the original Escherichia coli K-12 depending on forward-and-backward swimming, not on run-tumble movements

This study identifies a novel swimming behavior in E. coli K-12 strain ATCC10798, driven by forward-and-backward motion rather than run-tumble, linked to a mutation in FliC.

Sodium-powered stators of the bacterial flagellar motor can generate torque in the presence of phenamil with mutations near the peptidoglycan-binding region.

The paper identifies mutations in the sodium-powered bacterial flagellar motor stator PotB that confer resistance to phenamil, showing that mutations near the peptidoglycan-binding region enable motor function in the presence of the inhibitor.