Author

M. K. Axthelm

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Organism:rat· 3 Assay:proteomics· 2 Research Focus:drug response / drug discovery· 1 Organism:mouse· 1

Frequent Co-Authors

L. J. Picker· 4 shared S. G. Hansen· 4 shared A. B. Ventura· 3 shared C. M. Hughes· 3 shared D. Malouli· 3 shared J. Shao· 3 shared K. Früh· 3 shared A. N. Selseth· 2 shared

Activity by Year

2019-2020 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersImmunology

L. J. Picker

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Author profile →

4 papers

Recent·Most cited

Cytomegaloviral determinants of CD8+ T cell programming and RhCMV/SIV vaccine efficacy

D. Malouli, S. G. Hansen, M. H. Hancock, C. M. Hughes, J. C. Ford, R. M. Gilbride, A. B. Ventura, D. Morrow, H. Taher, L. S. Uebelhoer, M. R. McArdle, C. R. Papen, R. Espinosa Trethewy, K. Oswald, R. Shoemaker, , L. J. Picker

This study identifies eight genes in two RhCMV regions that control unconventional CD8+ T cell responses and vaccine efficacy against SIV challenge.

bioRxiv · Sep 30, 2020Immunology

Modulation of MHC-E transport by viral decoy ligands is required for RhCMV/SIV vaccine efficacy

M. Verweij, S. G. Hansen, R. Iyer, N. John, D. Malouli, D. Morrow, I. Scholz, J. Womack, S. Abdulhaqq, R. M. Gilbride, C. M. Hughes, A. B. Ventura, J. C. Ford, A. N. Selseth, K. Oswald, , K. Früh

This study shows that the Rh67/UL40 protein in RhCMV/SIV vectors is necessary for MHC-E-restricted CD8+ T cell responses and SIV protection in rhesus macaques.

bioRxiv · Sep 30, 2020Immunology

In vitro and in vivo characterization of a recombinant rhesus cytomegalovirus containing a complete genome

H. Taher, E. Mahyari, C. Kreklywich, L. S. Uebelhoer, M. R. McArdle, M. J. Moström, A. Bhusari, M. Nekorchuk, T. Whitmer, E. A. Scheef, L. M. Sprehe, D. Roberts, C. M. Hughes, K. A. Jackson, A. N. Selseth, , D. Malouli

This paper constructs a full-length rhesus cytomegalovirus (RhCMV) by repairing mutations in the 68-1 strain and shows it replicates more effectively in vivo compared to the passaged strain.

bioRxiv · Jun 2, 2020Microbiology

TGFβ restricts T cell function and bacterial control within the tuberculous granuloma

B. Gern, K. N. Adams, C. R. Plumlee, C. R. Stoltzfus, L. Shehata, K. Busman-Sahay, S. G. Hansen, M. K. Axthelm, L. J. Picker, J. D. Estes, K. B. Urdahl, M. Y. Gerner

This study shows that TGFβ suppresses T cell function and bacterial control in tuberculous granulomas by inhibiting IFNγ production in T helper 1 cells.

bioRxiv · Jul 9, 2019Immunology