Author

M. Y. Gerner

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 6 Bioengineering· 2

Signature Assays, Organisms & Methods

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Organism:mouse· 6 Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 4 Assay:imaging· 4 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Approach:microscopy & imaging analysis· 2 Research Focus:spatial domain detection· 2

Frequent Co-Authors

C. R. Stoltzfus· 5 shared C. R. Plumlee· 4 shared K. B. Urdahl· 4 shared B. H. Gern· 3 shared A. K. Glaser· 2 shared E. Shamskhou· 2 shared J. T. C. Liu· 2 shared L. A. Barner· 2 shared

Activity by Year

2019-2024 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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5 shared papersImmunology

C. R. Stoltzfus

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Author profile →

8 papers

Recent·Most cited

CD4-mediated immunity shapes neutrophil-driven tuberculous pathology

B. H. Gern, J. M. Klas, K. A. Foster, S. B. Cohen, C. R. Plumlee, F. J. Duffy, M. L. Neal, M. Halima, A. T. Gustin, A. H. Diercks, A. Aderem, M. Gale, J. D. Aitchison, M. Y. Gerner, K. B. Urdahl

This study shows that prior immunity influences tuberculosis lesion structure by modulating neutrophil and T cell responses, leading to different pathological outcomes.

bioRxiv · Apr 12, 2024Immunology

Prolonged T cell - DC macro-clustering within lymph node microenvironments initiates Th2 cell differentiation in a site specific manner

M. R. Lyons-Cohen, E. Shamskhou, M. Y. Gerner

The paper shows that Th2 cell differentiation in lymph nodes depends on site-specific macro-clustering of T cells and dendritic cells, driven by differences in cDC2 activation states.

bioRxiv · Jul 7, 2023 · PreprintImmunology

Multi-Parameter Quantitative Imaging of Tumor Microenvironments Reveals Perivascular Immune Niches Associated with Anti-Tumor Immunity

C. R. Stoltzfus, R. Sivakumar, L. Kunz, B. E. Olin Pope, E. Menietti, D. Speziale, R. Adelfio, M. Bacac, S. Colombetti, M. Perro, M. Y. Gerner

This study uses spatial analysis to show that perivascular immune niches are associated with anti-tumor immunity and are enhanced by immunotherapy.

bioRxiv · Jun 17, 2021Immunology

A hybrid open-top light-sheet microscope for multi-scale imaging of cleared tissues

A. K. Glaser, K. W. Bishop, L. A. Barner, E. A. Susaki, S. I. Kubota, G. Gao, R. B. Serafin, P. Balaram, E. Turschak, P. R. Nicovich, H. Lai, L. A. G. Lucas, Y. Yi, E. K. Nichols, H. Huang, , J. T. C. Liu

The paper introduces a hybrid light-sheet microscope that enables versatile multi-scale imaging of cleared tissues with varying resolution, geometry, and compatibility requirements.

bioRxiv · May 6, 2020Bioengineering

CytoMAP: a spatial analysis toolbox reveals features of myeloid cell organization in lymphoid tissues

C. R. Stoltzfus, J. Filipek, B. H. Gern, B. E. Olin, J. M. Leal, M. R. Lyons-Cohen, J. Huang, C. L. Paz-Stoltzfus, C. R. Plumlee, T. Pöschinger, K. B. Urdahl, M. Perro, M. Y. Gerner

CytoMAP is a spatial analysis toolbox that identifies cellular networks and tissue organization features in lymphoid tissues using 2D/3D imaging data.

bioRxiv · Nov 21, 2019Immunology

TGFβ restricts T cell function and bacterial control within the tuberculous granuloma

B. Gern, K. N. Adams, C. R. Plumlee, C. R. Stoltzfus, L. Shehata, K. Busman-Sahay, S. G. Hansen, M. K. Axthelm, L. J. Picker, J. D. Estes, K. B. Urdahl, M. Y. Gerner

This study shows that TGFβ suppresses T cell function and bacterial control in tuberculous granulomas by inhibiting IFNγ production in T helper 1 cells.

bioRxiv · Jul 9, 2019Immunology

BCG-induced T cells shape Mycobacterium tuberculosis infection before reducing the bacterial burden

J. L. Delahaye, B. H. Gern, S. B. Cohen, C. R. Plumlee, S. Shafiani, M. Y. Gerner, K. B. Urdahl

This study shows BCG vaccination shifts infected cell types in mice, with T cell activation preceding bacterial burden reduction.

bioRxiv · Apr 4, 2019 · PreprintImmunology

Multi-immersion open-top light-sheet microscope for high-throughput imaging of cleared tissues

A. K. Glaser, N. P. Reder, Y. Chen, C. Yin, L. Wei, S. Kang, L. A. Barner, W. Xie, E. F. McCarty, C. Mao, A. R. Halpern, C. R. Stoltzfus, J. S. Daniels, M. Y. Gerner, P. R. Nicovich, , J. T. C. Liu

The paper introduces a multi-immersion open-top light-sheet microscope for high-throughput imaging of cleared tissues using various clearing protocols.

bioRxiv · Feb 13, 2019Bioengineering