Author

L. J. Picker

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Immunology· 5 Microbiology· 3

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 7 Organism:rat· 6 Research Focus:host-pathogen & immune response· 5 Assay:proteomics· 4 Research Focus:cell type annotation· 2 Research Focus:clustering· 2 Research Focus:drug response / drug discovery· 2 Organism:human· 2

Frequent Co-Authors

S. G. Hansen· 6 shared D. Malouli· 4 shared M. K. Axthelm· 4 shared A. B. Ventura· 3 shared C. M. Hughes· 3 shared D. N. Streblow· 3 shared H. Taher· 3 shared J. Shao· 3 shared

Activity by Year

2019-2024 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

6 shared papersMicrobiology

S. G. Hansen

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Pre-challenge gut microbial signature predicts RhCMV/SIV vaccine efficacy in rhesus macaques

H. N. Brochu, E. Smith, S. Jeong, M. Carlson, S. G. Hansen, J. Tisoncik-Go, L. Law, L. J. Picker, M. Gale, X. Peng

The paper identifies a gut microbial signature predictive of RhCMV/SIV vaccine efficacy in rhesus macaques using 16S rRNA analysis and compositional data techniques.

bioRxiv · Feb 27, 2024Microbiology

The pentameric complex is not required for vertical transmission of cytomegalovirus in seronegative pregnant rhesus macaques

H.-Y. Wang, H. Taher, C. N. Kreklywich, K. A. Schmidt, E. A. Scheef, R. Barfield, C. E. Otero, S. Valencia, C. M. Crooks, A. Mirza, K. Woods, N. V. Burgt, T. F. Kowalik, P. A. Barry, S. G. Hansen, , D. Malouli

The study shows that deleting the pentameric complex in rhesus CMV does not affect congenital transmission in seronegative pregnant rhesus macaques.

bioRxiv · Jun 15, 2023 · PreprintMicrobiology

HLA-E restricted, HIV-1 suppressing, Gag specific CD8+ T cells offer universal vaccine opportunities

H. Yang, M. Rei, S. Brackenridge, E. Brenna, H. Sun, s. abdulhaqq, M. K. Liu, W. Ma, P. Kurupati, x. Xu, V. Cerundolo, E. Jenkins, S. J. Davis, J. B. Sacha, K. Frueh, , A. J. McMichael

The paper demonstrates that HLA-E restricted, HIV-1 specific CD8+ T cells can suppress HIV-1 replication in vitro, suggesting potential for a universal vaccine.

bioRxiv · Dec 1, 2020 · PreprintImmunology

Cytomegaloviral determinants of CD8+ T cell programming and RhCMV/SIV vaccine efficacy

D. Malouli, S. G. Hansen, M. H. Hancock, C. M. Hughes, J. C. Ford, R. M. Gilbride, A. B. Ventura, D. Morrow, H. Taher, L. S. Uebelhoer, M. R. McArdle, C. R. Papen, R. Espinosa Trethewy, K. Oswald, R. Shoemaker, , L. J. Picker

This study identifies eight genes in two RhCMV regions that control unconventional CD8+ T cell responses and vaccine efficacy against SIV challenge.

bioRxiv · Sep 30, 2020Immunology

Modulation of MHC-E transport by viral decoy ligands is required for RhCMV/SIV vaccine efficacy

M. Verweij, S. G. Hansen, R. Iyer, N. John, D. Malouli, D. Morrow, I. Scholz, J. Womack, S. Abdulhaqq, R. M. Gilbride, C. M. Hughes, A. B. Ventura, J. C. Ford, A. N. Selseth, K. Oswald, , K. Früh

This study shows that the Rh67/UL40 protein in RhCMV/SIV vectors is necessary for MHC-E-restricted CD8+ T cell responses and SIV protection in rhesus macaques.

bioRxiv · Sep 30, 2020Immunology

The identity of human tissue-emigrant CD8+ T cells

M. Buggert, L. A. Vella, S. Nguyen, V. Wu, T. Sekine, A. Perez-Potti, C. R. Maldini, S. Manne, S. Darko, A. Ransier, L. Kuri-Cervantes, A. Sada Japp, I. Bukh Brody, M. A. Ivarsson, L. Hertwig, , M. R. Betts

The paper characterizes tissue-emigrant CD8+ T cells in humans and non-human primates, revealing distinct migratory behaviors and clonal dynamics.

bioRxiv · Aug 11, 2020Immunology

In vitro and in vivo characterization of a recombinant rhesus cytomegalovirus containing a complete genome

H. Taher, E. Mahyari, C. Kreklywich, L. S. Uebelhoer, M. R. McArdle, M. J. Moström, A. Bhusari, M. Nekorchuk, T. Whitmer, E. A. Scheef, L. M. Sprehe, D. Roberts, C. M. Hughes, K. A. Jackson, A. N. Selseth, , D. Malouli

This paper constructs a full-length rhesus cytomegalovirus (RhCMV) by repairing mutations in the 68-1 strain and shows it replicates more effectively in vivo compared to the passaged strain.

bioRxiv · Jun 2, 2020Microbiology

TGFβ restricts T cell function and bacterial control within the tuberculous granuloma

B. Gern, K. N. Adams, C. R. Plumlee, C. R. Stoltzfus, L. Shehata, K. Busman-Sahay, S. G. Hansen, M. K. Axthelm, L. J. Picker, J. D. Estes, K. B. Urdahl, M. Y. Gerner

This study shows that TGFβ suppresses T cell function and bacterial control in tuberculous granulomas by inhibiting IFNγ production in T helper 1 cells.

bioRxiv · Jul 9, 2019Immunology