C. R. Plumlee

CD4-mediated immunity shapes neutrophil-driven tuberculous pathology

This study shows that prior immunity influences tuberculosis lesion structure by modulating neutrophil and T cell responses, leading to different pathological outcomes.

Re-appraising the role of T-cell derived interferon gamma in restriction of Mycobacterium tuberculosis in the murine lung

This study shows T cell-derived IFN-gamma is critical for controlling Mycobacterium tuberculosis in the murine lung, despite equivalent bacterial burdens in T cell-deficient mice.

Assessing vaccine-mediated protection in an ultra-low dose Mycobacterium tuberculosis murine model

This study evaluates BCG vaccine efficacy using an ultra-low dose Mtb murine model, showing enhanced protection compared to conventional models.

Attenuated Mycobacterium tuberculosis Vaccine Protection in a Low Dose Murine Challenge Model

This study shows that the live attenuated Mtb vaccine candidate ΔLprG provides better protection than BCG in a low dose murine challenge model, reducing detectable infection and containing it anatomically.

CytoMAP: a spatial analysis toolbox reveals features of myeloid cell organization in lymphoid tissues

CytoMAP is a spatial analysis toolbox that identifies cellular networks and tissue organization features in lymphoid tissues using 2D/3D imaging data.

TGFβ restricts T cell function and bacterial control within the tuberculous granuloma

This study shows that TGFβ suppresses T cell function and bacterial control in tuberculous granulomas by inhibiting IFNγ production in T helper 1 cells.

BCG-induced T cells shape Mycobacterium tuberculosis infection before reducing the bacterial burden

This study shows BCG vaccination shifts infected cell types in mice, with T cell activation preceding bacterial burden reduction.