Author

T. Sanyal

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biochemistry· 3 Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 4 Organism:human· 3 Research Focus:drug response / drug discovery· 2 Assay:proteomics· 2 Approach:Bayesian inference· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

a. Sali· 4 shared B. T. Chait· 3 shared M. P. Rout· 3 shared N. E. Ketaren· 3 shared P. C. Fridy· 3 shared F. D. Mast· 2 shared J. P. Olivier· 2 shared A. Li· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

4 shared papersBiochemistry

a. Sali

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Unique Binding and Stabilization Mechanisms Employed By and Engineered Into Nanobodies.

N. E. Ketaren, P. C. Fridy, V. Malashkevich, T. Sanyal, M. Brilliantes, M. K. Thompson, D. A. Orens, J. B. Bonanno, a. Sali, S. C. Almo, B. T. Chait, M. P. Rout

This study identifies mechanisms enabling nanobodies to bind antigens with high affinity and stability, revealing a conserved region critical for their function and suggesting strategies for their optimization.

bioRxiv · Oct 22, 2023 · PreprintBiochemistry

Nanobody repertoire generated against the spike protein of ancestral SARS-CoV-2 remains efficacious against the rapidly evolving virus

N. E. Ketaren, F. D. Mast, P. C. Fridy, J. P. Olivier, T. Sanyal, A. Sali, B. T. Chait, M. P. Rout, J. Aitchison

The paper shows that nanobodies against ancestral SARS-CoV-2 spike protein remain effective against recent variants, including omicron sublineages and emerging XBB/BQ.1.1 variants.

bioRxiv · Jul 14, 2023Biochemistry

Nanobody Repertoires for Exposing Vulnerabilities of SARS-CoV-2

F. D. Mast, P. C. Fridy, N. E. Ketaren, J. Wang, E. Y. Jacobs, J. P. Olivier, T. Sanyal, K. R. Molloy, F. Schmidt, M. Rutkowska, Y. Weisblum, L. M. Rich, E. R. Vanderwall, N. Dambrauskas, V. Vigdorovich, , M. P. Rout

This paper presents a large repertoire of high-affinity nanobodies against SARS-CoV-2 Spike protein with potent neutralization properties and resistance to viral variants.

bioRxiv · Apr 8, 2021Biochemistry

Bayesian metamodeling of complex biological systems across varying representations

B. Raveh, L. Sun, K. L. White, T. Sanyal, J. Tempkin, D. Zheng, K. Bharath Pilla, J. Singla, C. Wang, J. Zha, A. Li, N. A. Graham, C. Kesselman, R. C. Stevens, A. Sali

This paper introduces Bayesian metamodeling to integrate diverse models of biological systems, demonstrating its application to glucose-stimulated insulin secretion in pancreatic β-cells.

bioRxiv · Mar 29, 2021Cell Biology

Anti-cancer property of Lenzites betulina (L) Fr. on cervical cancer cell lines and its anti-tumor effect on HeLa-implanted mice

S. K. Ghosh, T. Sanyal

This study evaluates the anti-cancer properties of Lenzites betulina extract on cervical cancer cell lines and in mice, showing significant cell inhibition and tumor reduction.

bioRxiv · Feb 5, 2019 · PreprintCancer Biology