Author

M. Mietzsch

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Assay:cryo-EM· 3 Research Focus:protein structure prediction· 3 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Organism:bacteria (other)· 1 Research Focus:cell type annotation· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

M. Agbandje-Mckenna· 3 shared R. McKenna· 3 shared D. Lyumkis· 2 shared J. A. Hull· 2 shared S. Aiyer· 2 shared Y. Z. Tan· 2 shared A. Mehrani· 1 shared A. R. Nelson· 1 shared

Activity by Year

2018-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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3 shared papersBiophysics

M. Agbandje-Mckenna

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Structural characterization of antibody-responses from Zolgensma treatment provides the blueprint for the engineering of an AAV capsid suitable for redosing

M. Mietzsch, A. R. Nelson, J. Hsi, J. Zachary, L. Potts, P. Chipman, M. Ghanem, N. Khandekar, I. E. Alexander, G. J. Logan, J. T. Huiskonen, R. McKenna

This study uses cryo-EM to analyze antibodies against AAV9 vectors, identifying residues that enable capsid engineering to avoid neutralization and allow redosing.

bioRxiv · May 1, 2024 · PreprintImmunology

Overcoming Resolution Attenuation During Tilted Cryo-EM Data Collection

S. Aiyer, P. R. Baldwin, S. M. Tan, Z. Shan, J. Oh, A. Mehrani, M. E. Bowman, G. Louie, D. O. Passos, S. Đorđevic-Marquardt, M. Mietzsch, J. A. Hull, S. Hoshika, B. A. Barad, D. Grotjahn, , D. Lyumkis

This study improves cryo-EM data collection by reducing resolution attenuation during stage tilt, enabling isotropic map reconstruction of specimens with preferred orientations.

bioRxiv · Jul 14, 2023Biophysics

AAV Capsid Chimeras with Enhanced Infectivity reveal a core element in the AAV Genome critical for both Cell Transduction and Capsid Assembly

L. Viney, T. Bürckstümmer, M. Mietzsch, M. Choudhry, T. Henley, M. Agbandje-McKenna

This paper develops an AAV chimera, AAV-XV, with enhanced T cell transduction efficiency at lower doses and identifies a critical genomic region for both capsid assembly and transduction.

bioRxiv · Oct 13, 2020Cell Biology

Sub-2 A Ewald Curvature Corrected Single-Particle Cryo-EM

Y. Z. Tan, S. Aiyer, M. Mietzsch, J. A. Hull, R. McKenna, J. Grieger, R. J. Samulski, T. S. Baker, M. Agbandje-McKenna, D. Lyumkis

The paper improves cryo-EM resolution by correcting Ewald sphere curvature, achieving 1.86 Å resolution for an AAV2 variant.

Nature Communications · Sep 7, 2018Peer-reviewedBiophysics