S. Shimizu

Intradermal Administration of Rescue Dose of Antiemetics in Chemotherapy-induced Nausea and Vomiting

The paper compares the pharmacokinetics of subcutaneous and intradermal antiemetic administration in rats to evaluate their effectiveness for rapid, self-administered rescue therapy for chemotherapy-induced nausea and vomiting.

Artificial Intelligence Enables the Label-Free Identification of Chronic Myeloid Leukemia Cells with Mitochondrial Morphological Alterations

This study uses AI with flow cytometry to identify CML cells with mitochondrial morphological changes, enabling early diagnosis and monitoring of treatment response.

Covalent Targeting of Glutamate Cysteine Ligase to Inhibit Glutathione Synthesis

This study identifies a covalent inhibitor EN25 that targets GCLM to inhibit glutathione synthesis in ARID1A-deficient cancer cells.

Inhibition of the BMP pathway suppresses tumor growth via downregulation of EGFR in MEK/ERK-dependent colorectal cancer

This study shows that inhibiting the BMP pathway suppresses colorectal cancer growth by reducing EGFR, and combining BMP and MEK inhibition enhances therapeutic effects in patient-derived organoids.

Structure of a monomeric photosystem I core associated with iron-stress-induced-A proteins from Anabaena sp. PCC 7120

The paper determines the structure of a monomeric photosystem I core complex with IsiA proteins from Anabaena sp. PCC 7120 under iron deficiency, revealing their role in inhibiting PSI oligomerization.

A Novel Mouse Wound Model for Scar Tissue Formation in Abdominal-Muscle Wall

The paper develops a novel mouse model for scar tissue formation in the abdominal muscle wall without artificial factors, showing collagen-rich granulation tissue similar to human scars.

The effect of sword bean extract on the relationship between rheumatoid arthritis and periodontitis in mice

This study investigates how sword bean extract affects the interaction between rheumatoid arthritis and periodontitis in mice, finding that it reduces inflammation and bone resorption in both conditions.