M. Qiu

Neutrophil-derived complement factor P induces cytotoxicity in basal-like cells via caspase 3/7 activation in pancreatic cancer

This study shows that neutrophil-derived complement factor P induces apoptosis in basal-like pancreatic cancer cells via caspase 3/7 activation, linking properdin expression to better prognosis.

Dual Ethanolamine Head Groups in Ionizable Lipids Facilitate Phospholipid-free Stable Nanoparticle Formulation for Augmented and Safer mRNA Delivery

This paper introduces ionizable lipids with dual ethanolamine head groups for phospholipid-free mRNA delivery, showing improved stability, efficiency, and reduced toxicity.

ER mediates spatial regulation of lysosome-endosome interactions via motion switch at junction sites

The paper investigates how lysosomes and endosomes interact with the ER through spatial regulation, revealing a mechanism involving actin cytoskeleton condensation and the VAP-STARD3-YWHAH pathway.

Cross-species single-cell comparison of systemic and cardiac inflammatory responses after cardiac injury

This study compares systemic and cardiac inflammatory responses to injury in mice and zebrafish using single-cell transcriptomics, revealing distinct monocyte/macrophage transcriptional clusters and divergent responses between species.

Comprehensive characterization of tumor microenvironment in colorectal cancer via histopathology-molecular analysis

This study characterizes the tumor microenvironment in colorectal cancer using multi-omics and spatial analysis, identifying four subtypes with distinct features and therapeutic responses.

A high-throughput 3D cantilever array to model airway smooth muscle hypercontractility in asthma

The paper develops a 3D microtissue model of asthmatic airway smooth muscle to identify contractile modulators and validate their effects through RNAseq analysis.

Improved Heat Tolerance in Heat-acclimated Mice: the Probable Role of the PD-L1 Pathway

This study shows that heat-acclimated mice have more Tregs, which reduce inflammation and improve heat tolerance through the PD-1/PD-L1 pathway.

Effective infection with dengue virus in experimental neonate and adult mice through intranasal route

This study infects neonate and adult mice with dengue virus via the nasal route, showing viral tropism and replication in multiple tissues, suggesting respiratory transmission as a potential non-vector route.

Transcriptome profiling of Candidatus Liberibacter asiaticus in citrus and psyllids

This study profiles the transcriptome of Candidatus Liberibacter asiaticus in citrus and psyllids, identifying gene expression patterns and differentially expressed genes between hosts.

ESD1 Affects Seed Setting Rate in Rice by Controlling Embryo Sac Development

This study shows ESD1 regulates seed setting rate in rice by controlling embryo sac development, as loss-of-function mutants exhibit reduced seed setting rates and abnormal embryo sac differentiation.

An In Vivo Method for Diversifying the Functions of Therapeutic Antibodies

This paper develops a method to diversify therapeutic antibodies by mimicking natural B cell processes in mice, resulting in new antibodies with altered functions.