U. Kishore

The human complement factor B-C3b complex: Investigation of the interaction using C3b bound to thiol-Sepharose

This study investigates the interaction between factor B and C3b using competition assays, finding that specific antibodies can inhibit or enhance complex formation.

Spatial tumor immune heterogeneity facilitates subtype co-existence and therapy response via AP1 dichotomy in pancreatic cancer

The paper identifies AP1 transcription factor dichotomy and CD68+ macrophages as drivers of intratumoral subtype co-existence and therapy response in pancreatic cancer.

Neutrophil-derived complement factor P induces cytotoxicity in basal-like cells via caspase 3/7 activation in pancreatic cancer

This study shows that neutrophil-derived complement factor P induces apoptosis in basal-like pancreatic cancer cells via caspase 3/7 activation, linking properdin expression to better prognosis.

Activation of Complement by Human Fibrin Clots: involvement of C1q and factor H

This study shows fibrin clots activate the classical complement pathway, which is regulated by factor H, through covalent binding mediated by FXIIIa.

Mapping the interaction sites of Influenza A viruses and human complement Factor H

This study maps the interaction sites between Influenza A viruses and human complement Factor H, showing strain-specific effects on viral entry and replication.

The immunoglobulin A isotype of the Arabian camel (Camelus dromedarius) preserves the dualistic structure of unconventional single-domain and canonical heavy chains

This study identifies that the Arabian camel's IgA isotype expresses both unconventional single-domain and canonical heavy chains, similar to IgG, expanding the immunoglobulin repertoire.

Human complement Factor H and Properdin act as soluble pattern recognition receptors and differentially modulate SARS-CoV-2 Infection

This study shows that complement factors FH and FP interact with SARS-CoV-2 proteins and differentially modulate viral entry and inflammatory responses in A549 cells.

Human Surfactant Protein D Facilitates SARS-CoV-2 Pseudotype Binding and Entry in DC-SIGN Expressing Cells, and Downregulates Spike protein Induced Inflammation

This study shows that rfhSP-D enhances SARS-CoV-2 Spike protein binding to DC-SIGN and increases viral uptake in DC-SIGN-expressing cells while reducing inflammation.

A recombinant fragment of Human surfactant protein D binds Spike protein and inhibits infectivity and replication of SARS-CoV-2 in clinical samples

This study shows that a recombinant fragment of human SP-D inhibits SARS-CoV-2 spike protein binding to ACE-2 and reduces viral replication in clinical samples.

Human Surfactant Protein D Binds S1 and Receptor Binding Domain of Spike protein and acts as an entry inhibitor of SARS-CoV-2 Pseudotyped viral particles in vitro

This study shows that rfhSP-D binds SARS-CoV-2 S1 protein and inhibits viral entry into cells, suggesting its potential as an antiviral therapy.

Complement Component 3 expressed by the endometrial ectopic tissue is involved in the endometriotic lesion formation through mast cell activation

This study shows that complement component 3 from endometrial ectopic tissue promotes endometriotic lesion formation by activating mast cells in a murine model.