Author

M. R. Herod

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 7

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:host-pathogen & immune response· 4 Assay:cryo-EM· 2 Organism:human· 2 Organism:mouse· 2 Approach:microscopy & imaging analysis· 1 Research Focus:protein structure prediction· 1 Organism:virus· 1

Frequent Co-Authors

N. J. Stonehouse· 6 shared M. Harris· 4 shared D. M. Pierce· 2 shared J. S. Snowden· 2 shared A. Cox· 1 shared A. Tuplin· 1 shared C. E. Wobus· 1 shared C. J. McCormick· 1 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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6 shared papersMicrobiology

N. J. Stonehouse

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Author profile →

7 papers

Recent·Most cited

Insights into polyprotein processing and RNA-protein interactions in foot-and-mouth disease virus genome replication.

D. M. Pierce, D. Rowlands, N. J. Stonehouse, M. R. Herod

This study investigates how mutations at the 3B3-3C junction of FMDV affect polyprotein processing and replication, showing that altered processing impacts enzyme function and RNA interaction.

Journal of Virology · May 31, 2023Peer-reviewedMicrobiology

Amino acid substitutions in norovirus VP1 dictate cell tropism via an attachment process dependent on membrane mobility.

J. T. Mills, S. C. Minogue, J. S. Snowden, K. E. Carnahan, D. J. Rowlands, N. J. Stonehouse, C. E. Wobus, M. R. Herod

This study identifies an amino acid substitution in norovirus VP1 that enhances cellular attachment and alters tropism by affecting receptor recruitment and membrane mobility.

bioRxiv · Feb 17, 2023 · PreprintMicrobiology

Processing of the hepatitis E virus polyprotein can be mediated by a cellular protease

D. M. Pierce, F. J. T. Buchanan, A. Cox, K. M. Abualsaud, J. C. Ward, M. Harris, N. J. Stonehouse, M. R. Herod

This paper investigates hepatitis E virus polyprotein processing and finds that it relies on host proteases rather than viral proteases for replication.

bioRxiv · Dec 5, 2022 · PreprintMicrobiology

Hepatitis E virus genome replication is independent of cyclophilins A and B

F. J. Buchanan, S. Chen, M. Harris, M. R. Herod

This study investigates the role of cyclophilins A and B in HEV genome replication and finds they are not essential for replication of genotype 1 or 3 HEV, though CypB silencing reduces genotype 1 replication in some cells.

bioRxiv · Dec 5, 2022 · PreprintMicrobiology

Positive strand RNA viruses differ in the constraints they place on the folding of their negative strand

M. R. Herod, J. Ward, A. Tuplin, M. Harris, N. J. Stonehouse, C. J. McCormick

The paper investigates differences in conformational constraints on negative strand RNA folding among positive strand RNA viruses, finding significant variation in ribozyme activity and duplex formation.

bioRxiv · Feb 1, 2022Microbiology

Higher-order structures of the foot-and-mouth disease virus RNA-dependent RNA polymerase required for dynamic inter-molecular interactions involved in viral genome replication

E. A. Loundras, J. Streetley, M. R. Herod, R. F. Thompson, M. Harris, D. Bhella, N. J. Stonehouse

This study identifies higher-order structures of the foot-and-mouth disease virus RdRp and their role in RNA replication through cryo-EM and mutagenesis.

bioRxiv · Dec 17, 2020 · PreprintMicrobiology

High-Resolution Cryo-EM Reveals Dynamics in the Murine Norovirus Capsid

J. S. Snowden, D. L. Hurdiss, O. O. Adeyemi, N. A. Ranson, M. R. Herod, N. J. Stonehouse

This study uses cryo-EM to reveal the dynamic conformational changes in murine norovirus capsids, showing flexibility in protruding domains that impact virion stability and infectivity.

bioRxiv · Jul 4, 2019 · PreprintMicrobiology