M. Colome-Tatche

Cross-species analyses reveal RORγt-expressing dendritic cells are a lineage of antigen presenting cells conserved across tissues

The paper identifies RORγt-expressing dendritic cells as a distinct APC lineage conserved across tissues and species, with functions beyond promoting tolerance.

High-resolution scRNA-seq reveals genomic determinants of antigen expression hierarchy in African Trypanosomes

This study uses high-resolution scRNA-seq to uncover how genomic rearrangements during antigen switching in Trypanosoma brucei depend on repair mechanisms and homologous templates.

A compendium of Amplification-Related Gain Of Sensitivity (ARGOS) genes in human cancer

The paper identifies ARGOS genes, which are amplified in cancer, have low expression relative to copy number, and are toxic when overexpressed, and validates several as pan-cancer targets.

ARID1A Mutations Protect Follicular Lymphoma from FAS-dependent Immune Surveillance by Reducing RUNX3/ETS1-Driven FAS-Expression

This study identifies ARID1A mutations in follicular lymphoma that reduce FAS expression, enabling immune evasion by disrupting RUNX3/ETS1 regulation.

Single-cell metabolic profiling reveals subgroups of primary human hepatocytes showing heterogeneous responses to drug challenge.

The paper profiles metabolic responses of primary human hepatocytes to drug challenge and fatty acid accumulation, revealing four subgroups with distinct transcriptional responses.

Cancer tolerance to chromosomal instability is driven by Stat1 inactivation in vivo

The paper identifies Stat1 inactivation as a mechanism by which aneuploid cancers evade immune surveillance in mice and humans.

Region-level Epimutation Rates in Arabidopsis thaliana

The paper shows region-level epimutations in Arabidopsis thaliana occur at similar rates to single CG methylation changes and are not limited to CG contexts.

Ecological plant epigenetics: Evidence from model and non-model species, and the way forward

The paper reviews epigenetic contributions to plant ecology and proposes integrating model-species research with non-model species studies to better understand ecological processes.