Author
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
5 papers
Recent·Most cited
S. Sinha, A. M. Molina Vargas, P. R. Arantes…·G. Palermo
This study elucidates the allosteric activation mechanism of CRISPR-Cas13a using molecular dynamics simulations and experiments, revealing key residues critical for RNA cleavage selectivity.
J. Hollinger, J. Wu, K. M. Awayda…·P. Yao
This study develops a method to purify human FAM210A, a mitochondrial transmembrane protein, using E. coli and validates its interaction with EF-Tu.
E. J. Walker, J. Q. Bettinger, K. A. Welle…·S. Ghaemmaghami
The paper shows that oxidation rates of buried methionines correlate with protein folding stability, using E. coli and T. thermophilus proteomes to demonstrate this relationship.
A. R. VanderWal, J.-U. Park, B. Polevoda…·M. R. O'Connell
The paper shows Csx28 forms a membrane pore activated by Cas13b to slow metabolism and inhibit viral infection.
A. Tambe, A. East-Seletsky, G. J. Knott…·M. R. O'Connell
This study shows that RNA binding and nuclease activation in CRISPR-Cas13a are separate processes, with distinct requirements for guide-target base pairing.